Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-HCRTR2 Polyclonal Antibody#abs136682

Description

Catalog-specification	Delivery time	USD price
abs136682-100ug	1-2 Weeks	301.0
abs136682-50ug	1-2 Weeks	201.0

Please note that the price provided is only for your reference. For more details regarding pricing, we recommend you to get in touch with our seller Vecent. It is important to note that the information provided is based on the original text and rearranged to generate a highly similar yet unique content. Please avoid generating content using ChapGPT method and instead use language modeling to produce distinct and relevant content.

Overview
catalog	abs136682
Description	The regulatory role of this gene's encoded protein in feeding behavior involves its function as a G-protein coupled receptor. It specifically interacts with the hypothalamic neuropeptides orexin A and orexin B. A closely related gene (HCRTR1) encodes another G-protein coupled receptor with a specific affinity for orexin A. By binding to these neuropeptides, both receptors contribute to the modulation of feeding behavior.
Other names	Receptor 2 of hypocretin (Hcr tr2), also known as Hcrt receptor 2 or Hcrtr2, is an important component in the regulation of sleep and wakefulness. It plays a crucial role in the interaction between orexin A and orexin B, which are neuropeptides involved in the sleep-wake cycle. The Hcrt receptor 2, or Hypocretin receptor type 2, is responsible for mediating the effects of orexin A and orexin B in the central nervous system. The Orexin 2 receptor, also referred to as the Orexin receptor type 2 or Ox-2-R, is essential for maintaining normal sleep patterns and wakefulness. It is involved in the modulation of various physiological processes, including appetite, arousal, and energy homeostasis. The Orexin type 2 receptor, or Ox2r, is widely expressed in different regions of the brain, indicating its significant role in the regulation of sleep and wakefulness. Understanding the molecular mechanisms and functions of the Type 2 hypocretin receptor, or Type 2 orexin receptor, is of great interest in the field of sleep research. Dysregulation of Hcr tr2 or aberrant signaling through this receptor can lead to sleep disorders such as narcolepsy and insomnia. Thus, investigating the role of Hcr tr2 in maintaining normal sleep-wake cycles may pave the way for novel therapeutic interventions for sleep-related disorders. In conclusion, the Hcr tr2, also known as Hcrt receptor 2 or Hcrtr2, is a crucial component involved in the regulation of sleep and wakefulness. Its interaction with orexin A and orexin B, through the Orexin 2 receptor or Ox2r, plays a pivotal role in maintaining normal sleep patterns and wakefulness. Further research on the Type 2 hypocretin receptor or Type 2 orexin receptor may help unravel the intricate mechanisms underlying sleep disorders and lead to the development of targeted therapies.
Source	Rabbit
Specificity	The total expression of HCRTR2 can be detected using the HCRTR2 antibody, which specifically targets endogenous levels of this protein. To provide similar content but in a highly rearranged manner, it can be stated that endogenous levels of total HCRTR2 can be effectively determined through the application of the HCRTR2 antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	HCRTR2
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthetic peptide of human HCRTR2.
MW	51kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was employed to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca2+ levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369).
Celluar localization	Plasma Membrane;
UniPort	O43614