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Rabbit Anti-GGH Polyclonal Antibody#abs141152

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Description

Catalog-specification	Delivery time	USD price
abs141152-100ug	1-2 Weeks	301.0
abs141152-50ug	1-2 Weeks	201.0

Overview
catalog	abs141152
Other names	Gamma-glutamyl hydrolase, also known as GGH or conjugase, is an enzyme that plays a crucial role in the breakdown of folylpolygammaglutamates. It is also referred to as folylpolygammaglutamyl hydrolase and gamma-glutamyl carboxypeptidase. Conjugase, or gamma-glutamyl hydrolase, is involved in the hydrolysis of the gamma-glutamyl bond in various biologically active compounds. This enzyme is essential for the metabolism of folate derivatives, including folic acid, which is an essential vitamin for cell growth and division. The GGH enzyme acts as a carboxypeptidase, cleaving the gamma-glutamyl residues from peptides and proteins. By removing these residues, it helps regulate the levels of gamma-glutamylated compounds in the body. GGH, encoded by the GGH_HUMAN gene, is highly conserved across species and is found in various tissues throughout the body. Its activity is crucial for maintaining the balance of folate derivatives and other gamma-glutamylated compounds in cells. In summary, gamma-glutamyl hydrolase, also known as GGH or conjugase, is an important enzyme involved in the metabolism of folylpolygammaglutamates and other gamma-glutamylated compounds. Its function as a carboxypeptidase is crucial for maintaining the proper balance of these compounds in the body.
Source	Rabbit
Specificity	The GGH Antibody is capable of recognizing total levels of GGH that are present naturally within the organism. In order to create a substantially similar content, the key ideas of the original text have been retained, but have been expressed through different wording and sentence structures. It has been noted by the original text that the GGH Antibody is capable of detecting endogenous amounts of total GGH.
Species Reactivity	Human;Mouse
Predictive reaction species	Horse
Antigen	GGH
Application	For Western blotting, a dilution range of 1:500 to 1:1000 is recommended. When performing immunofluorescence or immunocytochemistry, it is suggested to dilute the antibody at a range of 1:100 to 1:500. For ELISA assays using peptide antigens, a dilution range of 1:20000 to 1:40000 is optimal. It is important to carefully consider the antibody dilution when conducting these experiments to ensure accurate and reliable results.
Immunogen	A synthesized peptide.
MW	36 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed in the purification process of the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	One should keep the product frozen at a temperature of -20°C for a duration of one year. It is essential to prevent the product from undergoing multiple freeze/thaw cycles.
Storage buffer	Phosphate buffered saline containing Rabbit IgG is formulated with pH 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this solution at -20 °C. The stability of the product is guaranteed for a period of 12 months from the date of receipt.
Target
Background	Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
Celluar localization	Cytosol;Extracellular region or secreted;Lysosome;Nucleus;
UniPort	Q92820