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Rabbit Anti-FYB Polyclonal Antibody#abs137290

Description

Catalog-specification	Delivery time	USD price
abs137290-100ug	1-2 Weeks	301.0
abs137290-50ug	1-2 Weeks	201.0

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Overview
catalog	abs137290
Other names	FYB, also known as adhesion and degranulation promoting adaptor protein (ADAP), is a vital protein involved in cellular adhesion and signaling pathways. It is also referred to as Fyb, FYB-120/130, or FYN-binding protein. FYB is a binding partner of FYN, and it acts as an adaptor protein that connects FYN to downstream signaling molecules. Another name for FYB is FYN T-binding protein, as it interacts with FYN tyrosine kinase. It is important to note that FYB is specific to humans and is encoded by the FYB_HUMAN gene. FYB, alternatively called p120/p130 or SLAP 130, has been identified as a SLP-76-associated phosphoprotein. It plays a crucial role in signal transduction, particularly in the activation of immune cells. In summary, FYB is a versatile protein involved in adhesion and degranulation processes, interacting with FYN and facilitating signaling cascades. Its association with SLP-76 underscores its significance in immune cell function.
Source	Rabbit
Specificity	Endogenous levels of total FYB are detected by the FYB Antibody. The antibody is able to identify and recognize the specific protein, allowing researchers to study its properties and functions. This tool is particularly useful for those studying cellular signaling pathways and protein-protein interactions. By detecting FYB at the endogenous level, researchers can better understand its role in various biological processes and potentially develop new therapies for related diseases.
Species Reactivity	Human;Mouse;Rat
Antigen	FYB
Application	： - ，WB，1:1000-3000。 - IHC，1:200，。 - IF/ICC，1:100-1:500，。 - ELISA(peptide)，1:20000-1:40000，。，，。
Immunogen	A synthesized peptide derived from human FYB.
MW	110 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed for peptide affinity chromatography in order to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at a temperature of -20°C for a period of one year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing in order to prevent damage to its structural integrity.
Storage buffer	This product contains Rabbit IgG that has been suspended in a solution of phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. It is advised that the product should be stored at -20 °C in order to maintain its stability for a period of 12 months from the date of receipt.
Target
Background	Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton.
Tissue specificity	Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues.
Posttranslational modification	T-cell receptor ligation leads to increased tyrosine phosphorylation.
Celluar localization	Cytoskeleton;Cytosol;Nucleus;Plasma Membrane;
UniPort	O15117