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Rabbit Anti-FOG2 Polyclonal Antibody#abs138372

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Description

Catalog-specification	Delivery time	USD price
abs138372-100ug	1-2 Weeks	301.0
abs138372-50ug	1-2 Weeks	201.0

Overview
catalog	abs138372
Other names	Friend of GATA2, also known as FOG-2, is a zinc finger protein called FOG2_HUMAN. It is closely associated with GATA protein 2 and plays a significant role in gene regulation. Another name for FOG2 is hFOG-2. Zinc finger protein 89B and Zinc finger protein M2 are alternative names for FOG2, highlighting its diverse functions. It is a member of the zinc finger protein multitype 2 family and is encoded by the gene ZFPM2. FOG2 acts as a friend or partner of GATA2 in various cellular processes. Its role in transcriptional regulation makes it an essential player in the development and functioning of many organ systems.
Source	Rabbit
Specificity	The FOG2 Antibody is capable of detecting the natural levels of total FOG2 within a given system. By targeting specific epitopes, this antibody allows for the accurate assessment of endogenous FOG2 levels. This detection method is valuable in understanding the role and regulation of FOG2 in various biological processes.
Species Reactivity	Human;Mouse
Predictive reaction species	Rabbit;Horse;
Antigen	FOG2
Application	The dilution ratios for WB and IHC are as follows: WB at 1:1000-3000 and IHC at 1:200. The dilution ratio for ELISA using peptide is between 1:20000 to 1:40000. It is important to follow these dilution guidelines when performing these assays to ensure accurate results.
Immunogen	A synthesized peptide derived from human FOG2.
MW	128kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum has been purified through peptide affinity chromatography. A highly effective and precise method of purification, it allows for the specific and targeted removal of unwanted compounds, ensuring the final product is of the highest quality. The resulting antiserum is purified to a level where it is highly effective and reliable for use in a wide range of applications.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the integrity of the product, it is recommended to store it at a temperature of -20 °C for up to one year. It is important to avoid subjecting the product to repeated freeze and thaw cycles as this may affect its efficacy. Ensure that the storage condition is optimal to extend the product's shelf life and maintain its potency.
Storage buffer	This product consists of rabbit IgG dissolved in a solution of phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For optimal stability, it is recommended to store this product at a temperature of -20 °C. With proper storage, this product can remain stable for up to 12 months from the date of receipt.
Target
Background	Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity).
Tissue specificity	Widely expressed at low level.
Posttranslational modification	Sumoylation reduces transcriptional repression activity.
Celluar localization	Nucleus;
UniPort	Q8WW38