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Rabbit Anti-CRAM1 Polyclonal Antibody#abs137022

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Description

Catalog-specification	Delivery time	USD price
abs137022-100ug	1-2 Weeks	301.0
abs137022-50ug	1-2 Weeks	201.0

Overview
catalog	abs137022
Other names	Junctional adhesion molecule 3, also known as JAM-2, JAM-3, JAM-C, FLJ14529, or JAM3, is a protein that plays an essential role in intercellular adhesion and migration. Encoded by the JAM3 gene, this protein is expressed in various tissues, including the vascular endothelial cells, leukocytes, and platelets. It is a type-I transmembrane protein that belongs to the immunoglobulin superfamily, and it interacts with other proteins like JAM-1 to form tight junctions, which regulate the paracellular permeability of endothelial and epithelial cells. JAM-3 is also involved in leukocyte transmigration and platelet activation, and it is an important mediator of inflammation and angiogenesis. Defects in this protein have been associated with various diseases, such as cancer, autoimmune disorders, and cardiovascular disorders. Overall, JAM-3 is a versatile and important protein with many diverse functions in cellular biology.
Source	Rabbit
Specificity	The CRAM1 Antibody is capable of detecting total CRAM1 levels in a natural setting. Its ability to identify endogenous CRAM1 levels makes it a valuable tool in research and experimentation.
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Sheep;Dog;Bovine;Horse
Antigen	CRAM1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CRAM1.
MW	60 kDa
Properties
Concentration	1mg/ml
purification	Through the use of SulfoLink™ Coupling Resin, peptide affinity chromatography was utilized to purify the antiserum to its highest quality.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain optimal storage conditions, it is recommended to store the item at a temperature of -20 °C for a duration of one year. It is crucial to prevent the item from undergoing repeated freeze/thaw cycles.
Storage buffer	-20°C，IgG(pH7.4)、150mM、0.02%50%。，12。。
Target
Background	Participates in cell-cell adhesion. It is a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis.
Tissue specificity	Highest expression in placenta, brain and kidney. Significant expression is detected on platelets. Expressed in intestinal mucosa cells. Expressed in the vascular endothelium. Found in serum (at protein level). Also detected in the synovial fluid of patients with rheumatoid arthritis, psoriatic arthritis or ostearthritis (at protein level).
Posttranslational modification	Proteolytically cleaved from endothelial cells surface into a soluble form by ADAM10 and ADAM17; the release of soluble JAM3 is increased by proinflammatory factors.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	Q9BX67