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Rabbit Anti-CRADD Polyclonal Antibody#abs135780

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Description

Catalog-specification	Delivery time	USD price
abs135780-50ug	1-2 Weeks	201.0
abs135780-100ug	1-2 Weeks	301.0

Overview
catalog	abs135780
Other names	The protein known as CASP2 and RIPK1 domain containing adaptor with death domain is also referred to as Caspase and RIP adapter with death domain or Caspase and RIP adaptor with death domain. Another name for this protein is Cradd or CRADD_HUMAN, which stands for Death adaptor molecule RAIDD. It is also known as Death domain containing protein CRADD, MGC9163, RIP associated ICH1/CED3 homologous protein with death domain, and RIP associated protein with a death domain. Essentially, all of these names refer to the same protein, which is involved in cell death signaling pathways.
Source	Rabbit
Specificity	The CRADD Antibody is capable of detecting overall levels of endogenous CRADD. This information remains true to the original content but presents it in a different manner by rearranging the text.
Species Reactivity	Human;Mouse;Rat
Antigen	CRADD
Application	The dilution ranges for WB, IHC, and ELISA (peptide) are as follows: WB is typically diluted at a ratio of 1:500 to 1:2000, IHC is generally diluted at a ratio of 1:50 to 1:200, and for ELISA (peptide) the recommended dilution range is 1:20000 to 1:40000.
Immunogen	A synthesized peptide derived from human CRADD.
MW	23kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography in order to purify the antiserum. To provide a closely related version, the original text information can be rearranged as follows: By employing SulfoLink™ Coupling Resin, the antiserum was effectively purified through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for up to one year. It's important to note that the substance should not be subjected to repeated episodes of freezing and thawing. Taking these measures will help ensure that the product remains stable and effective throughout its intended shelf life.
Storage buffer	The storage conditions for Rabbit IgG are as follows: it should be stored at -20 °C in phosphate buffered saline at a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The IgG is stable for a period of 12 months from the date of receipt.
Target
Background	Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.
Tissue specificity	Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.
Celluar localization	Cytosol;Nucleus;
UniPort	P78560