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Rabbit Anti-CLNS1A Polyclonal Antibody#abs141239

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Description

Catalog-specification	Delivery time	USD price
abs141239-100ug	1-2 Weeks	301.0
abs141239-50ug	1-2 Weeks	201.0

Overview
catalog	abs141239
Other names	ICln, also known as Chloride channel nucleotide sensitive 1A or Chloride channel regulatory protein, is an important protein involved in regulating chloride ion conductance. It is also known as Chloride conductance regulatory protein ICln, Chloride ion current inducer protein, Methylosome subunit pICln, Reticulocyte pICln, and Reticulocyte protein ICln. CLNS 1A and Clns1a are other names used to refer to this protein. ICln is known to be a volume-sensitive channel that activates in response to changes in cell volume. Through its ability to regulate chloride ion conductance, ICln plays an important role in many physiological processes, including cell volume regulation, membrane potential stabilization, and pH regulation. ICln is encoded by the CLNS1A and CLNS1B genes, with CLNS1A being the primary isoform expressed in humans. Mutations in the CLNS1A gene have been linked to various disorders, including cystic fibrosis and cardiac arrhythmia. Overall, ICln is a critical protein that plays an important role in regulating ionic homeostasis and maintaining normal cellular function. Its intricate mechanisms make it a promising target for developing future therapies for various diseases.
Source	Rabbit
Specificity	The total CLNS1A levels can be effectively detected with the CLNS1A Antibody, which specifically targets the endogenous expression of CLNS1A protein. To rephrase the content in a highly similar manner, the antibody is capable of identifying the overall levels of CLNS1A within biological samples through its affinity for the endogenous CLNS1A protein.
Species Reactivity	Human
Predictive reaction species	Sheep;Rabbit;Horse;Pig;
Antigen	CLNS1A
Application	，。，，1:5001:1000。/，1:1001:500。（ELISA），1:200001:40000。。，。
Immunogen	A synthesized peptide.
MW	37 KD
Properties
Concentration	1mg/ml
purification	We utilized SulfoLink™ Coupling Resin to perform peptide affinity chromatography and achieve purification of the antiserum. To create a highly similar content while rearranging the information from the original text, the following can be stated: Peptide affinity chromatography was employed to purify the antiserum, where SulfoLink™ Coupling Resin was utilized for this purpose.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is advisable to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to repeated freeze/thaw cycles during this period.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.
Celluar localization	Cytoskeleton;Cytosol;Nucleus;Plasma Membrane;
UniPort	P54105