Rabbit Anti-CLEC4D Polyclonal Antibody#abs136577
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Description
| Catalog-specification | Delivery time | USD price |
abs136577-100ug | 1-2 Weeks | 301.0 |
abs136577-50ug | 1-2 Weeks | 201.0 |
Please note that the price provided is for reference only. For more detailed pricing information, please contact our seller Vecent. It is important to remember that any information provided in this message is based on the original text. If you require further assistance, please do not hesitate to reach out to our customer service team.
| Overview | |
catalog | abs136577 |
Description | The described gene belongs to the superfamily of C-type lectin/C-type lectin-like domains (CTL/CTLD). These proteins share a similar protein structure and serve various functions, such as cell adhesion, cell signaling, glycoprotein turnover, and playing a critical role in the immune response and inflammation. This gene is situated in the natural killer gene complex region on chromosome 12p13 and is closely linked to other members of the CTL/CTLD superfamily. [RefSeq, Jul 2008] |
| Other names | C-type lectin receptors are a diverse group of proteins that play crucial roles in the recognition of carbohydrates and calcium-dependent binding. One member of this superfamily is C-type lectin domain family 4, member D, also known as CLEC-6 or Clec4d. This receptor, encoded by the CLECSF8 gene, is responsible for calcium-dependent lectin activity. Another closely related protein is C-type lectin superfamily member 8, which shares similar structural characteristics and functions. Additionally, C-type lectin-like receptor 6, also referred to as Macrophage C type lectin or MCL, belongs to this family of receptors and is associated with immune responses and pathogen recognition. These receptors have been identified as important players in various biological processes, including immune surveillance and cell adhesion. |
| Source | Rabbit |
| Specificity | The total CLEC4D levels in the body can be detected using the CLEC4D antibody, which is capable of identifying the endogenous levels of this protein. To create similar content, the original text can be rearranged and reworded to convey the same information. |
| Species Reactivity | Human;Mouse;Rat |
| Antigen | CLEC4D |
| Application | The dilution range for Western blotting is 1:500-1:2000, for immunohistochemistry it is 1:50-1:200, and for ELISA (peptide) it is 1:20000-1:40000. |
| Immunogen | A synthesized peptide derived from human CLEC4D. |
| MW | 25kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography in the purification process of the antiserum. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells. |
| Tissue specificity | Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma. |
| Celluar localization | Plasma Membrane; |
| UniPort | Q8WXI8 |
Western blot analysis of extracts of 293T cellline, using CLEC4D antibody|Immunohistochemistryof paraffin-embeddedhuman liver cancer tissue usingCLEC4D antibody.
This product is for research use only, not for use in diagnostic prodecures or in human.
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