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Rabbit Anti-CD42b Polyclonal Antibody#abs138039

Description

Catalog-specification	Delivery time	USD price
abs138039-100ug	1-2 Weeks	301.0
abs138039-50ug	1-2 Weeks	201.0

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Overview
catalog	abs138039
Other names	Alpha antigen CD42b; BDPLT1; BDPLT3; BSS; CD 42b; CD42b alpha; CD42B; CD42b antigen; DBPLT3; GLYCOCALICIN; Glycoprotein Ib (platelet) alpha polypeptide; Glycoprotein Ibalpha; GP Ib alpha; GP1B; GP1BA; GPIb alpha; GPIbA; MGC34595; Platelet glycoprotein Ib alpha chain; Platelet glycoprotein Ib alpha polypeptide; Platelet membrane glycoprotein 1b alpha subunit; VWDP; are all different names and aliases for the same protein. This protein is commonly referred to as CD42b alpha. It is a glycoprotein found on the surface of platelets and plays a crucial role in platelet adhesion and aggregation during blood clot formation. The CD42b alpha protein is composed of subunits and is part of the larger glycoprotein Ib-IX-V complex. It specifically binds to von Willebrand factor, a molecule involved in platelet adhesion and clot formation. Dysfunction or mutations in the CD42b alpha protein can lead to bleeding disorders, such as Bernard-Soulier syndrome or platelet-type von Willebrand disease. Understanding the structure and function of CD42b alpha is important for studying platelet biology and developing therapies for related disorders.
Source	Rabbit
Specificity	The antibody CD42b is designed to specifically recognize and bind to the total CD42b protein present in the body. Its purpose is to detect and measure the levels of endogenous CD42b, providing important information about its expression and function.
Species Reactivity	Human;Mouse
Antigen	CD42b
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CD42b.
MW	68 kDa
Properties
Concentration	1mg/ml
purification	Through the use of SulfoLink™ Coupling Resin, the antiserum was purified via peptide affinity chromatography. The process involved selectively binding and isolating the desired peptides, resulting in a highly purified and effective antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain optimal storage conditions for one year, it is recommended to store the item at a temperature of -20 °C. It is important to avoid subjecting it to repetitive freeze/thaw cycles.
Storage buffer	This product contains Rabbit IgG in a solution that includes phosphate buffered saline at a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol for enhanced stability. It is recommended to store this product at -20°C, and it should remain stable for up to 12 months from the date of receipt.
Target
Background	GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.
Posttranslational modification	Glycocalicin, which is approximately coextensive with the extracellular part of the molecule, is cleaved off by calpain during platelet lysis.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P07359