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Rabbit Anti-CCL21 Polyclonal Antibody#abs136201

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Description

Catalog-specification	Delivery time	USD price
abs136201-100ug	1-2 Weeks	301.0
abs136201-50ug	1-2 Weeks	201.0

Overview
catalog	abs136201
Description	Located on the p-arm of chromosome 9, this particular gene is part of a cluster of CC cytokine genes. Cytokines, a group of secreted proteins, are vital in regulating the immune system and inflammation. The distinguishing feature of CC cytokines is the presence of two adjacent cysteines. Like other chemokines, the protein produced by this gene hampers the production of blood cells and triggers chemotaxis. In laboratory experiments, this protein has exhibited chemotactic properties specifically towards thymocytes and activated T cells, while it fails to attract B cells, macrophages, and neutrophils. Additionally, this cytokine may have a pivotal role in guiding lymphocytes to secondary lymphoid organs. It acts as a high-affinity functional ligand for chemokine receptor 7, which is expressed in T and B lymphocytes and is also a known receptor for another member of the cytokine family known as small inducible cytokine A19.
Other names	Beta-chemokine exodus-2, also known as 6Ckine, is a chemokine that belongs to the C-C motif ligand family. It is also called CCL21 and is known to be an efficient chemoattractant for lymphocytes. This chemokine plays a crucial role in the immune system by attracting lymphocytes to secondary lymphoid tissues. It also plays a role in the migration of dendritic cells to T-cell areas of the lymph nodes. SCYA21, SLC, and TCA4 are other names for this chemokine. The gene that codes for CCL21 is located on chromosome 9 in humans. It is a small, inducible cytokine A21 that belongs to the cysteine-cysteine subclass.
Source	Rabbit
Specificity	The total CCL21 levels can be detected by the CCL21 Antibody, allowing for the measurement of endogenous concentrations. A rearranged version of the provided content is as follows: Detection of endogenous levels of total CCL21 is possible through the use of the CCL21 Antibody.
Species Reactivity	Human;Mouse;Rat
Antigen	CCL21
Application	The recommended dilutions for WB are between 1:500 to 1:2000, IHC should be diluted between 1:50 to 1:200, and ELISA for peptide detection requires a dilution of 1:20000 to 1:40000. These dilution ranges ensure optimal results for each specific application. Dilutions outside of these ranges may result in less accurate results and may require further optimization. It is important to always follow the recommended protocols and perform proper controls for each experimental setup to ensure accurate and reliable data interpretation.
Immunogen	A synthesized peptide derived from human CCL21.
MW	15kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Tissue specificity	Highly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver, and pancreas. Also found in tonsil, fetal heart and fetal spleen.
Celluar localization	Extracellular region or secreted;
UniPort	O00585