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Rabbit Anti-CCL20 Polyclonal Antibody#abs132640

Please note that the price stated above is for reference purposes only. For more accurate details, kindly get in touch with our sales representative, Vecent. Western blot analysis of CCL20 expression in HEK293 cells ,The lane on the left is treated with the antigen-specific peptide. This product...

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Description

Catalog-specification	Delivery time	USD price
abs132640-100ug	1-2 Weeks	301.0
abs132640-50ug	1-2 Weeks	201.0

Please note that the price stated above is for reference purposes only. For more accurate details, kindly get in touch with our sales representative, Vecent.

Overview
catalog	abs132640
Description	This chemotactic factor attracts lymphocytes and, to a lesser extent, neutrophils, while it does not affect monocytes. It plays a role in inhibiting the growth of myeloid progenitors in colony formation assays. Additionally, it may be involved in the development and functioning of mucosal lymphoid tissues by attracting dendritic cells and lymphocytes towards epithelial cells. It is noteworthy that processed forms at the C-terminal region also exhibit chemotactic activity towards leukocytes. Moreover, this factor possesses antibacterial properties against E.coli ATCC 25922 and S.aureus ATCC 29213.
Other names	One of the chemokines that play a critical role in the immune system is CCL20. It is also known as beta-chemokine exodus-1, CC chemokine ligand 20, or liver and activation-regulated chemokine. This chemokine belongs to the CC chemokine family and is responsible for attracting immune cells to the site of inflammation. Aside from its role in the immune system, CCL20 has been implicated in various diseases, such as cancer and autoimmune disorders. Due to its important role in the immune system, it is being studied as a potential therapeutic target for these diseases. CCL20 has also been shown to play a role in the maintenance of intestinal homeostasis. It is produced by intestinal epithelial cells and attracts immune cells to the gut, contributing to the regulation of the gut immune response. In summary, CCL20 is a critical chemokine that serves as a key player in the immune system and has potential therapeutic applications for various diseases.
Source	Rabbit
Specificity	The CCL20 antibody is capable of identifying the total amount of endogenous CCL20 present in the sample. This means that the antibody can specifically target and bind to CCL20 molecules in order to accurately detect their levels. The detection of CCL20 can be essential in various research and diagnostic applications. By rearranging the structure of the original content, we are able to convey the same message in a different way.
Species Reactivity	Human;Mouse
Predictive reaction species	Rabbit;Pig;Dog
Antigen	CCL20
Application	The dilution range for Western blot (WB) analysis is typically between 1:500 and 1:2000. For immunohistochemistry (IHC), the recommended dilution range is 1:50 to 1:200. In the case of ELISA using peptide antigens, the optimal dilution range is 1:20000 to 1:40000. Please note that the information provided here is based on the original text and has been rearranged to maintain its original meaning.
Immunogen	A synthesized peptide.
MW	11 kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:11352563, PubMed:11035086, PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (PubMed:9038201, PubMed:11352563). Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-terminal processed forms have been shown to be equally chemotactically active for leukocytes (PubMed:11035086). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:23765988, PubMed:25122636). Inhibits proliferation of myeloid progenitors in colony formation assays (PubMed:9129037). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (By similarity). Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213 (PubMed:12149255).
Tissue specificity	Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon.
Posttranslational modification	C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes.
Celluar localization	Extracellular region or secreted;
UniPort	P78556