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Rabbit Anti-AIMP1 Polyclonal Antibody#abs136773

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Description

Catalog-specification	Delivery time	USD price
abs136773-100ug	1-2 Weeks	301.0
abs136773-50ug	1-2 Weeks	201.0

Overview
catalog	abs136773
Description	This gene encodes a protein that is strictly induced by apoptosis and plays a critical role in the regulation of angiogenesis, inflammation, and wound healing. Its release makes the vasculature of a tumor more receptive to tumor necrosis factor. In normal cells, the precursor protein, which is identical to the p43 subunit, assists in modulating aminoacylation activity of tRNA synthetase. After it is cleaved in tumor cells, it stimulates inflammatory responses. There are various transcript variants for this gene coding for different isoforms. A pseudogene has been located on chromosome 20.
Other names	AIMP1, also known as Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 or ARS interacting multifunctional protein 1, is a human gene. It is also referred to as AIMP1/p43 or AIMP1_HUMAN. AIMP1 is associated with various functions and pathways in the body. Another name for AIMP1 is EMAP 2 or EMAP-2, which stands for Endothelial monocyte activating polypeptide 2. This protein plays a role in activating monocytes and endothelial cells. It is also known as EMAP-II or Endothelial monocyte-activating polypeptide II. AIMP1 is also referred to as EMAPII, which is short for Endothelial monocyte activating polypeptide. This protein is involved in regulating endothelial cells and monocyte activation. Another name for AIMP1 is p43, which is derived from its molecular weight of 43 kilodaltons. It is a component of the multisynthase complex and serves as an auxiliary protein. Additionally, AIMP1 is sometimes called Scye 1, which is short for Small inducible cytokine subfamily E member 1. This protein belongs to the small inducible cytokine subfamily E and is involved in various cellular functions. In summary, AIMP1 is a multifunctional protein involved in various cellular processes and pathways. It is known by multiple names, including AIMP1/p43, EMAP 2, EMAP-II, EMAPII, p43, and Scye 1.
Source	Rabbit
Specificity	The AIMP1 Antibody is capable of detecting the complete amount of AIMP1 present in the body. This recognition occurs with no interference from external factors.
Species Reactivity	Human;Mouse;Rat
Antigen	AIMP1
Application	The recommended dilutions for WB are 1:500-1:2000, for IHC they are 1:50-1:200, and for ELISA using peptide, the suggested dilutions are 1:20000-1:40000. It is important to follow these guidelines to achieve accurate and reliable results. Dilution factors outside of these ranges may result in weaker signal or excessive background noise. It is always advisable to optimize the dilution for each specific experiment to obtain the best possible data.
Immunogen	A synthesized peptide derived from human AIMP1.
MW	34kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLinkâ„¢ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 Â°C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 Â°C.Stable for 12 months from date of receipt.
Target
Background	Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.
Posttranslational modification	Cleaved by caspase-7 in response to apoptosis to produce EMAP-II.
Celluar localization	Cytosol;Endoplasmic reticulum;Extracellular region or secreted;Golgi apparatus;Nucleus;
UniPort	Q12904