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Rabbit Anti-AICDA Polyclonal Antibody#abs137412

Please note that the price mentioned above is only for your reference. For detailed pricing, we recommend reaching out to our seller, Vecent. Western blot analysis AICDA using COLO205 whole cell lysates This product is for research use only, not for use in diagnostic prodecures or in human.

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Description

Catalog-specification	Delivery time	USD price
abs137412-100ug	1-2 Weeks	301.0
abs137412-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing, we recommend reaching out to our seller, Vecent.

Overview
catalog	abs137412
Other names	AID, also known as Activation-induced cytidine deaminase or Activation induced deaminase, is a protein involved in the immune response. It is encoded by the AICDA gene in humans and is commonly referred to as AICDA_HUMAN. AID plays a crucial role in the generation of antibodies by B cells. Another name for AID is ARP2, or ARP 2. It is also referred to as CDA2 or CDA 2, which stands for Cytidine aminohydrolase. AID is integrated into Burkitt's lymphoma cell line Ramos, a cell line derived from a tumor commonly found in the jaw or abdomen. Activation-induced cytidine deaminase operates by deaminating cytidine residues in DNA, resulting in the formation of uracil. This process is called somatic hypermutation and is responsible for the introduction of genetic diversity in the variable region of immunoglobulins. AID is also involved in class switch recombination, which allows B cells to switch the type of antibody they produce. Mutations in the AICDA gene can lead to Hyper-IgM syndrome type 2 (HIGM2), a rare immune disorder characterized by high levels of circulating IgM and low levels of other antibody types. Defects in AID function impair somatic hypermutation and class switch recombination, leading to an impaired immune response. In summary, Activation-induced cytidine deaminase, or AID, is a key player in the immune response, responsible for genetic diversification of antibodies. It is encoded by the AICDA gene and is involved in somatic hypermutation and class switch recombination. Mutations in AID can result in Hyper-IgM syndrome type 2, causing immune system dysfunction. Furthermore, AID is integrated into the Burkitt's lymphoma cell line Ramos, contributing to its pathogenesis.
Source	Rabbit
Specificity	The total AICDA levels can be detected using the AICDA Antibody, which specifically targets the endogenous expression of AICDA protein.
Species Reactivity	Human
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	AICDA
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human AICDA.
MW	24 kDa
Properties
Concentration	1mg/ml
purification	We utilized SulfoLink™ Coupling Resin in peptide affinity chromatography to purify the antiserum. Be mindful that the generated content might be completely different from the original text and not follow the style of ChapGPT.
Clonality	Polyclonal Antibody
Stability & Storage	-20°C，/。
Storage buffer	The storage condition for Rabbit IgG is in phosphate buffered saline with a pH of 7.4. It contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The recommended storage temperature is -20 °C. The stability of the product is guaranteed for a period of 12 months starting from the date of receipt.
Target
Background	Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894).
Tissue specificity	Strongly expressed in lymph nodes and tonsils.
Posttranslational modification	Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity.Probably monoubiquitinated on several residues by RNF126.
Celluar localization	Nucleus;
UniPort	Q9GZX7