Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-ACVR2A Polyclonal Antibody#abs136253

Please note that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our seller, Vecent. We recommend reaching out to Vecent for accurate and up-to-date pricing details. Western blot analysis of extracts of mouse brain, using ACVR2A...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs136253-100ug	1-2 Weeks	301.0
abs136253-50ug	1-2 Weeks	201.0

Overview
catalog	abs136253
Description	Activins, members of the transforming growth factor-beta (TGF-beta) superfamily, exert their functions through a receptor encoded by this gene. This receptor, a transmembrane serine-threonine kinase, plays a crucial role in signaling by forming complexes with type I and type II receptors and ligands specific to each cell type. The encoded type II receptor mainly functions in ligand binding and consists of an extracellular ligand-binding domain, a transmembrane domain, and a cytoplasmic serine-threonine kinase domain. This gene's variants may be linked to increased susceptibility to preeclampsia, a dangerous pregnancy-related condition that poses risks to both mother and fetus. Multiple transcript variants can arise from alternative splicing of this gene.
Other names	The Activin A receptor type IIA, also known as Activin receptor type 2A or Activin receptor type IIA, is a crucial protein involved in various cellular processes in the human body. It belongs to the family of transforming growth factor-beta (TGF-β) receptors and plays a vital role in the regulation of different signaling pathways. ACTR 2, ACTR IIA, ACTR-IIA, ACTR2, ACTRII, ACTRIIA, Acvr 2, Acvr 2A, Acvr2, ACVR2A, AVR2A_HUMAN, and OTTHUMP00000197918 are several names used to refer to this protein. It serves as a transmembrane receptor that binds to activin and other ligands to initiate downstream signaling processes. The activation of Activin A receptor type IIA plays a crucial role in various cellular activities, including cell proliferation, differentiation, and apoptosis. It also participates in the development of numerous organs and systems in the human body, such as the skeletal system, nervous system, and reproductive system. Several studies have linked Activin A receptor type IIA to various pathophysiological conditions, including cancer, cardiovascular diseases, and neurodegenerative disorders. Therefore, this protein is being extensively researched as a potential therapeutic target for several diseases.
Source	Rabbit
Specificity	The ACVR2A Antibody is able to detect total ACVR2A levels that occur naturally within an organism. This means it is highly effective for identifying and monitoring the presence of this protein. To create similarly informative content, the original text could be rephrased as follows: "Total ACVR2A levels can be accurately identified using the ACVR2A Antibody, which is specifically designed to detect endogenous levels of this protein. This makes it an excellent tool for monitoring ACVR2A activity within biological samples."
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep;Horse;
Antigen	ACVR2A
Application	The recommended dilution range for WB is between 1:500-1:2000, while for IHC it is between 1:50-1:200. For ELISA using peptide, a dilution of 1:20000-1:40000 is suggested. It is important to carefully follow the recommended dilution ranges to ensure accurate and reliable results. Dilution factors that are too high or too low can lead to false-positive or false-negative results, respectively. It is also important to consider factors such as sample type and antibody specificity when selecting the appropriate dilution range.
Immunogen	A synthesized peptide derived from human ACVR2A.
MW	57kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).
Celluar localization	Plasma Membrane;
UniPort	P27037