enLanguage
Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details
Phospho-Torc1/Crtc1 (Ser151) Rabbit Polyclonal Antibody#abs140347

Phospho-Torc1/Crtc1 (Ser151) Rabbit Polyclonal Antibody#abs140347

Please note that the price mentioned above is for your reference only. For detailed pricing information, kindly get in touch with our seller, Vecent. Western blot analysis Torc1/Crtc1 (Phospho-Ser151) using PMA treated Jurkat whole cell lysates This product is for research use only, not for use...

Send Inquiry

Description

Catalog-specificationDelivery timeUSD price

abs140347-100ug

1-2 Weeks

301.0

abs140347-50ug

1-2 Weeks

201.0

Please note that the price mentioned above is for your reference only. For detailed pricing information, kindly get in touch with our seller, Vecent.


Overview

catalog

abs140347
Other namesCREB-regulated transcription coactivator 1 (KIAA0616), also known as CRTC1, is a protein that plays a crucial role in transcriptional regulation. It is commonly referred to as mucoepidermoid carcinoma translocated protein 1 (MECT1) or transducer of regulated cAMP response element-binding protein 1 (TORC1). This multifunctional protein acts as a coactivator for CREB, a transcription factor involved in cellular processes such as cell growth, metabolism, and learning and memory.
CRTC1 functions by binding to CREB and enhancing its transcriptional activity, thereby influencing the expression of various target genes. This coactivation occurs through a series of phosphorylation events that regulate the subcellular localization and activity of CRTC1. When activated by cellular signals, CRTC1 translocates from the cytoplasm to the nucleus, where it interacts with CREB and other transcriptional machinery to facilitate gene expression.
The dysregulation of CRTC1 has been implicated in several diseases, including cancer. In particular, chromosomal translocations involving CRTC1 have been identified in mucoepidermoid carcinomas, a type of salivary gland cancer. These translocations result in the fusion of CRTC1 with the MAML2 gene, leading to the constitutive activation of CRTC1-mediated transcriptional pathways. This aberrant activation contributes to the development and progression of mucoepidermoid carcinomas.
Further research on CRTC1 is essential for understanding its precise role in transcriptional regulation and its potential as a therapeutic target. By unraveling the complex mechanisms underlying CRTC1 function, scientists can gain insights into cellular processes and identify novel strategies for the treatment of various diseases.
SourceRabbit
SpecificityThe Torc1/Crtc1 (Phospho-Ser151) Antibody is specifically designed to recognize and bind to Torc1/Crtc1 protein only when it is phosphorylated at Ser151. This antibody enables the detection of endogenous levels of Torc1/Crtc1 that have undergone phosphorylation at Ser151.
Species ReactivityHuman;Mouse
Predictive reaction speciesXenopus;Chicken;Pig;Dog;Horse;Sheep;Bovine
AntigenTorc1/Crtc1
ApplicationWB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
ImmunogenA human Torc1/Crtc1 peptide synthesized from Phospho-Ser151 has been developed. To create similar content based on the original text information, one could rephrase the statement as follows: A peptide, derived from human Torc1/Crtc1 and containing Phospho-Ser151, has been synthesized for research purposes.
MW67kDa
Properties

Concentration

1mg/ml

purificationThe affinity-purified antibody originated from purified rabbit serum and was obtained through sequential chromatography using phospho- and non-phospho-peptide affinity columns. Please note that the requested generated content should be significantly distinct from the original text information and not be generated in a conversational manner like ChapGPT.
ClonalityPolyclonal Antibody
Stability & StorageStore at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage bufferRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Target

Background

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.

Tissue specificityHighly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.
Posttranslational modificationPhosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1 (By similarity).
Celluar localizationCytosol;Nucleus;Plasma Membrane;
UniPortQ6UUV9


Western blot analysis Torc1/Crtc1 (Phospho-Ser151) using PMA treated Jurkat whole cell lysates


This product is for research use only, not for use in diagnostic prodecures or in human.


Hot Tags: phospho-torc1/crtc1 (ser151) rabbit polyclonal antibody#abs140347, China phospho-torc1/crtc1 (ser151) rabbit polyclonal antibody#abs140347 suppliers

You Might Also Like

Shopping Bags