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Phospho-L-plastin (Ser5) Rabbit Polyclonal Antibody#abs139916

Phospho-L-plastin (Ser5) Rabbit Polyclonal Antibody#abs139916

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Description

Catalog-specificationDelivery timeUSD price

abs139916-100ug

1-2 Weeks

301.0

abs139916-50ug

1-2 Weeks

201.0

Please note that the price mentioned is for your reference only. For the detailed price, please get in touch with our seller, Vecent. To generate a highly similar content, we request you not to follow the conversation generation style of ChapGPT and instead focus on delivering a speech in a completely distinct manner using the language model.


Overview

catalog

abs139916
Other namesL-plastin, also known as lymphocyte cytosolic protein 1 or plastin 2, is a larval cuticle protein that plays a crucial role in cellular movement and migration. It is encoded by the CP64 gene and is primarily expressed in white blood cells, specifically T cells and natural killer cells. L-plastin binds to actin filaments and crosslinks them, promoting the formation of actin bundles and increasing cell motility. It has been implicated in various physiological processes, including immune response, wound healing, and cancer metastasis. Despite its importance, the exact mechanisms of L-plastin function are not fully understood, and further research is necessary to elucidate its role in disease pathology and therapeutic potential.
SourceRabbit
SpecificityThe antibody against L-plastin (Phospho-Ser5) specifically recognizes the presence of phosphorylated L-plastin at Ser5. It is capable of detecting endogenous levels of L-plastin, as long as it is phosphorylated at Ser5. To provide content that is highly similar but rearranged, we can say: The detection of endogenous levels of L-plastin using the L-plastin (Phospho-Ser5) antibody is dependent on the phosphorylation of L-plastin at Ser5. This antibody is designed to specifically recognize and bind to phosphorylated L-plastin at Ser5, allowing for the identification and analysis of this posttranslational modification.
Species ReactivityHuman
Predictive reaction speciesPig;Rabbit;Sheep;Dog;Bovine;Horse;
AntigenL-plastin
ApplicationThe suggested antibody dilutions for Western blotting range from 1:1000 to 1:3000. For immunohistochemistry, the recommended dilutions are between 1:50 and 1:200. When performing ELISA with peptide antigens, a dilution range of 1:20000 to 1:40000 is advised. It is important to follow these dilution guidelines for accurate and reliable results in these experimental techniques.
ImmunogenHuman L-plastin is the source of a synthesized peptide known as phospho-Ser5. I would like to generate a highly similar content by rearranging the information provided in the original text. However, I will avoid using the conversational style used in ChapGPT and instead provide a unique way of presenting the information.
MW70kDa
Properties

Concentration

1mg/ml

purificationSequential chromatography was utilized to purify the antibody from rabbit serum, utilizing affinity purification on both phospho- and non-phospho-peptide affinity columns. The purified antibody was obtained through this process.
ClonalityPolyclonal Antibody
Stability & StorageTo maintain the stability of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to multiple freeze/thaw cycles.
Storage bufferThe Rabbit IgG solution is composed of phosphate buffered saline with a pH of 7.4, 0.02% sodium azide, 150mM NaCl, and 50% glycerol. This solution should be stored at -20°C and will remain stable for up to 12 months from the date of receipt.

Target

Background

Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.

Tissue specificityDetected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.
Posttranslational modificationPhosphorylated on a serine residue in response to costimulation through TCR/CD3 and CD2 or CD28. Serine phosphorylation promotes association with the actin cytoskeleton and targeting to peripheral cell projections.
Celluar localizationCytoskeleton;Cytosol;Extracellular region or secreted;Plasma Membrane;
UniPortP13796


Western blot analysis L-plastin (Phospho-Ser5) using 293 whole cell lysates


This product is for research use only, not for use in diagnostic prodecures or in human.


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