Recombinant Human Ubiquitin-Conjugating Enzyme E2 A/UBE2A (N-GST, 6His) #abs04310

abs04310-10ug

1-2 Weeks

46

abs04310-50ug

1-2 Weeks

115

abs04310-500ug

1-2 Weeks

963

abs04310-1mg

1-2 Weeks

1310

Description

Our E.coli expression system successfully produces Recombinant Human Ubiquitin-Conjugating Enzyme E2 A. The gene encoding Met1-Cys152 is expressed with a GST, 6His tag at the N-terminus. We have effectively utilized our expression system to generate this protein.

Other names

RAD6 Homolog A, also known as Ubiquitin-Conjugating Enzyme E2 A or HR6A, is a critical protein that is involved in the ubiquitination pathway. This protein plays a crucial role in the transfer of ubiquitin between the E1 and E3 enzymes, thus enabling the tagging of specific target proteins for degradation.
hHR6A, or Ubiquitin Carrier Protein A, can also function as a Ubiquitin-Protein Ligase, mediating the attachment of ubiquitin to specific substrates. This process is essential for many cellular events, such as DNA repair, cell cycle regulation, and immune response.
UBEA is the human homolog of yeast RAD6, and has a highly conserved structure and function. The RAD6A protein is involved in a variety of genetic and cellular processes, including DNA damage repair, replication, transcription, and apoptosis.
Overall, RAD6 Homolog A is a multifunctional and critical protein that plays a fundamental role in maintaining cellular homeostasis and function. Its importance in regulating essential cellular events makes it an exciting target for therapeutic interventions in the treatment of various diseases.

Source

Escherichia coli.

Format

This solution is provided in a filtered form with a size of 0.2 μm and contains 50mM HEPES, 150mM NaCl, 2mM DTT, and 10% glycerol. The pH level is maintained at 7.5 for optimum performance.

Properties

aa_sequence

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Concentration

The purity of the sample was found to be over 95% after conducting SDS-PAGE analysis. To rephrase the above statement, we can say that, by performing SDS-PAGE, it was established that the sample had a purity greater than 95%. Another way to convey the same information can be "SDS-PAGE analysis revealed that the sample had a purity exceeding 95%."

Endotoxin_level

The LAL test determined that the content should have a concentration of less than 0.1 ng/μg (1 IEU/μg). Please rearrange the given information to generate highly similar content.

Stability & Storage

，-20°C，6。，。

Target

Background

Ubiquitin-Conjugating Enzyme E2 (UBE2A) is a member of the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2A catalyzes the covalent attachment of ubiquitin to other proteins. UBE2A is required for postreplication repair of UV-damaged DNA. UBE2A Interacts with RAD18 and WAC.

Accession

P49459