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Rabbit Anti-UBASH3A Polyclonal Antibody#abs134852

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Description

Catalog-specification	Delivery time	USD price
abs134852-100ug	1-2 Weeks	301.0
abs134852-50ug	1-2 Weeks	201.0

Overview
catalog	abs134852
Other names	T cell ubiquitin ligand protein, also known as Cbl interacting protein 4 or CLIP4, is a crucial regulator of T cell receptor signaling. It is encoded by the UBASH3A gene and is also referred to as TULA-1 or STS-2. This protein contains an ubiquitin-binding domain and an SH3 domain, which are involved in various cellular processes. T cell ubiquitin ligand protein functions by interacting with Cbl proteins, another group of important signaling molecules. This interaction plays a critical role in regulating T cell activation and signaling pathways. Through its ubiquitin ligase activity, T cell ubiquitin ligand protein controls the degradation of key signaling molecules, thus fine-tuning T cell responses. Interestingly, T cell ubiquitin ligand protein has been implicated in the development and progression of certain diseases. For example, it has been linked to autoimmune disorders and cancer. Dysregulation of this protein can lead to aberrant T cell activation and contribute to the pathogenesis of these diseases. In conclusion, T cell ubiquitin ligand protein, also known as Cbl interacting protein 4, is a key player in T cell receptor signaling, regulating T cell activation and fine-tuning immune responses. Its involvement in disease processes highlights its potential as a therapeutic target for various disorders.
Source	Rabbit
Specificity	The total UBASH3A levels can be effectively detected by the UBASH3A Antibody, thereby enabling the measurement of endogenous UBASH3A levels.
Species Reactivity	Human
Antigen	UBASH3A
Application	1:5001:1000，/（IF/ICC）1:1001:500，（ELISA）（）1:200001:40000。，。
Immunogen	A synthesized peptide.
MW	74 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography purification of the antiserum. The resulting purified antiserum was highly effective for its intended purposes.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20°C for a period of one year. It is important to avoid any kind of repeated freeze and thaw cycles as this may affect the composition and efficacy of the product. Therefore, make sure to follow the storage instructions carefully to ensure that the product remains stable and effective for a longer period.
Storage buffer	The rabbit IgG is suspended in a buffer solution containing phosphate and saline, with a slightly alkaline pH of 7.4. It is fortified with 150mM of sodium chloride, and a small amount of sodium azide to prevent bacterial growth. The solution is further stabilized with 50% glycerol and should be stored at subzero temperature (-20°C) to ensure its longevity for up to 12 months after receipt.
Target
Background	Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.
Tissue specificity	Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.
Celluar localization	Cytosol;Extracellular region or secreted;Nucleus;
UniPort	P57075