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Rabbit Anti-TRPM8 Polyclonal Antibody#abs137443

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Description

Catalog-specification	Delivery time	USD price
abs137443-100ug	1-2 Weeks	301.0
abs137443-50ug	1-2 Weeks	201.0

Overview
catalog	abs137443
Other names	LTrpC-6, also known as Long transient receptor potential channel 6 or MGC2849, is a cationic channel belonging to the transient receptor potential (TRP) family. It is the short form of the TRPM8 channel and is also referred to as Transient receptor potential p8, TRP p8, or Trp-p8. This channel is encoded by the TRPM8 gene in humans, and its official gene symbol is TRPM8_HUMAN or TRPP8.
Source	Rabbit
Specificity	Endogenous levels of total TRPM8 can be detected using TRPM8 Antibody. This antibody is designed to specifically target TRPM8 and can identify the protein in various samples. By using this antibody, researchers can accurately assess the expression level of TRPM8 in different tissue or experimental conditions. This powerful tool is an essential part of investigations into the function and regulation of TRPM8, an important member of the transient receptor potential (TRP) family of ion channels.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine
Antigen	TRPM8
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human TRPM8.
MW	128 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Ensure that the content is stored at -20 °C for a year without experiencing repetitive freezing and thawing cycles.
Storage buffer	The rabbit IgG is formulated in phosphate buffered saline with a pH of 7.4, containing 150 millimolar NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this product at -20 °C and it will remain stable for up to a year from the date of receipt. These storage conditions will help ensure the antibody remains in optimal condition for downstream applications.
Target
Background	Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.
Tissue specificity	Expressed in prostate. Also expressed in prostate tumors and in non-prostatic primary tumors such as colon, lung, breast and skin tumors.
Celluar localization	Endoplasmic reticulum;Plasma Membrane;
UniPort	Q7Z2W7