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Rabbit Anti-STEAP1 Polyclonal Antibody#abs138138

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Description

Catalog-specification	Delivery time	USD price
abs138138-100ug	1-2 Weeks	301.0
abs138138-50ug	1-2 Weeks	201.0

Overview
catalog	abs138138
Other names	STEAP1, also known as Six transmembrane epithelial antigen of prostate, is an intriguing metalloreductase. It plays a crucial role in reducing metal ions in various biochemical processes. Another name for STEAP1 is PRSS 24 or PRSS24. Additionally, it is referred to as MGC19484 in some studies. STEAP1 is encoded by the gene 2410007B19Rik in humans. This metalloreductase possesses six transmembrane domains, making it an integral membrane protein. It is primarily expressed in the prostate gland, indicating its potential involvement in prostate-related functions. The significance of STEAP1 lies in its ability to reduce metal ions, which could have implications in cellular processes such as redox homeostasis and iron metabolism. Interestingly, the expression of STEAP1 has been observed in other tissues apart from the prostate. This suggests its potential involvement in diverse biological functions beyond the prostate. The exact mechanisms by which STEAP1 regulates metal ion reduction and its functional significance in these alternative tissues are yet to be fully elucidated. In summary, STEAP1, also known as Six transmembrane epithelial antigen of prostate, is an important metalloreductase involved in metal ion reduction. While primarily expressed in the prostate, its expression has been noted in other tissues as well. Further research is required to uncover the precise role of STEAP1 in different biological contexts and its potential implications for human health.
Source	Rabbit
Specificity	The detection of total STEAP1 is made possible by the specificity of the STEAP1 Antibody, which effectively identifies the endogenous levels present in a sample. This antibody enables the recognition and measurement of the overall expression of STEAP1 protein. By accurately detecting the total STEAP1 content, valuable insights can be gained into its role and function within biological systems.
Species Reactivity	Human;Rat
Antigen	STEAP1
Application	The recommended dilutions for WB are between 1:1000-3000, for IHC it is suggested to use a dilution of 1:200, and for ELISA with peptide it is advised to use dilutions between 1:20000-1:40000. These dilutions have been carefully calculated based on the original content and are essential for achieving optimal results in experiments. It is important to follow these recommendations for proper sample preparation and reliable interpretation of data.
Immunogen	A synthesized peptide derived from human STEAP1.
MW	39 kDa
Properties
Concentration	1mg/ml
purification	To purify the antiserum, SulfoLink™ Coupling Resin was utilized in peptide affinity chromatography. This process ensures that the antiserum is highly purified and of high quality. By using this technique, the antiserum is free from contaminants and impurities that may compromise its efficacy. Overall, peptide affinity chromatography is a reliable and efficient method for purifying the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality and effectiveness of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. Repeated freezing and thawing cycles should be avoided, as this can compromise the integrity of the product. It is important to adhere to these storage guidelines in order to ensure optimal performance.
Storage buffer	Phosphate buffered saline (PBS) containing Rabbit IgG is an ideal solution for various applications. It has a pH of 7.4 and includes 150mM NaCl, 0.02% sodium azide, and 50% glycerol. To maintain its stability and effectiveness, it should be stored at a temperature of -20 °C. This formulation ensures that the Rabbit IgG remains viable for up to 12 months from the date of receipt. Whether for research or diagnostic purposes, this product guarantees reliable and consistent results.
Target
Background	Metalloreductase that has the ability to reduce both Fe3+ to Fe2+ and Cu2+ to Cu1+. Uses NAD+ as acceptor (By similarity).
Tissue specificity	Ubiquitously expressed. Highly expressed in prostate tumors.
Celluar localization	Endosome;Plasma Membrane;
UniPort	Q9UHE8