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Rabbit Anti-SHANK2 Polyclonal Antibody#abs134803

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Description

Catalog-specification	Delivery time	USD price
abs134803-100ug	1-2 Weeks	301.0
abs134803-50ug	1-2 Weeks	201.0

Overview
catalog	abs134803
Other names	Shank2, also known as Cortactin binding protein 1 or Cortactin SH3 domain-binding protein, is an important protein involved in synaptic function. It is encoded by the gene CTTNBP1 or Cortactin-binding protein 1, also referred to as CortBP1. Other names for this protein include GKAP/SAPAP interacting protein or GKAP/SAPAP-interacting protein, KIAA1022, and Proline-rich synapse-associated protein 1 (ProSAP1). Additionally, it is also known as SH3 and multiple ankyrin repeat domains 2 (SHANK) or SH3 and multiple ankyrin repeat domains protein 2. In some cases, it is referred to as SPANK-3. Shank2 plays a vital role in the organization and stability of synapses, which are the connections between neurons. It interacts with various proteins and molecules to regulate synaptic structure and function. Its presence is essential for proper synaptic development and plasticity. Understanding the functions of Shank2 can provide insights into neurological disorders like autism spectrum disorder (ASD) and schizophrenia, as mutations in its gene have been associated with these conditions. Studying Shank2 can enhance our knowledge of the molecular mechanisms underlying these disorders and potentially contribute to the development of targeted therapeutic interventions. In summary, Shank2, a Cortactin-binding protein, is critically involved in synaptic function. Its role in synapse organization and stability makes it a crucial player in normal brain function and the development of neurological disorders.
Source	Rabbit
Specificity	The total SHANK2 levels can be effectively identified by the SHANK2 Antibody, enabling the detection of endogenous expressions of SHANK2.
Species Reactivity	Human;Mouse
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Horse
Antigen	SHANK2
Application	。WB1:5001:1000，IF/ICC1:1001:500，ELISA(peptide)1:200001:40000。。
Immunogen	A synthesized peptide.
MW	135 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in purifying the antiserum through peptide affinity chromatography. This effective method generated a highly purified antiserum, providing reliable results.
Clonality	Polyclonal Antibody
Stability & Storage	-20°C，。
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
Tissue specificity	Isoform 3 is present in epithelial colonic cells (at protein level).
Celluar localization	Cytosol;Plasma Membrane;
UniPort	Q9UPX8