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Rabbit Anti-RMP Polyclonal Antibody#abs138236

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Description

Catalog-specification	Delivery time	USD price
abs138236-100ug	1-2 Weeks	301.0
abs138236-50ug	1-2 Weeks	201.0

Overview
catalog	abs138236
Other names	C19orf2, also known as Chromosome 19 open reading frame 2, is a protein involved in various cellular processes. The protein is also referred to as NNX3, NNX3 protein, PPP1R19, Protein NNX3, Protein phosphatase 1 regulatory subunit 19, RMP, RMP_HUMAN, RNA polymerase II subunit 5 mediating protein, RNA polymerase II subunit 5-mediating protein, RPB5 mediating protein, RPB5-mediating protein, Unconventional prefoldin RPB5 interactor 1, Unconventional prefoldin RPB5 interactor, URI, URI1, and URI1, prefoldin-like chaperone. C19orf2 plays a critical role in regulating the activity of protein phosphatase 1 (PP1), which is involved in various cellular processes, including cell division and metabolism. It acts as a regulatory subunit of PP1, mediating its interaction with specific substrates and modulating its activity. Additionally, C19orf2 has been shown to interact with RNA polymerase II subunit 5 (RPB5), a key component of the RNA polymerase II complex involved in transcription. This interaction suggests that C19orf2 may play a role in regulating gene expression and RNA synthesis. Moreover, C19orf2 has been identified as an unconventional prefoldin RPB5 interactor, indicating its involvement in protein folding and assembly. It acts as a chaperone-like protein, assisting in the proper folding and stabilization of other proteins. In summary, C19orf2, also known as URI1, is a multifunctional protein involved in regulating protein phosphatase 1 activity, interacting with RNA polymerase II subunit 5, and functioning as a prefoldin-like chaperone. Its diverse roles highlight its importance in maintaining cellular integrity and function.
Source	Rabbit
Specificity	The detection of endogenous levels of total RMP is accomplished by the RMP Antibody. The content can be rearranged as follows: The RMP Antibody is capable of identifying the total RMP in its natural state.
Species Reactivity	Human;Mouse
Predictive reaction species	Zebrafish;Chicken;Rabbit;Xenopus;Dog;Horse;Bovine;Sheep;Pig
Antigen	RMP
Application	IHC 1:200, WB 1:1000-3000, IF/ICC 1:100-1:500, and ELISA (peptide) 1:20000-1:40000 are the recommended dilutions for different applications. It is important to follow these guidelines to ensure accurate results. Altering the dilution ratios may lead to incorrect interpretations. Therefore, it is crucial to carefully arrange the dilutions and use them accordingly.
Immunogen	A synthesized peptide derived from human RMP.
MW	56 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly refined form of the antiserum was obtained through this process.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the integrity of the product, it is advised to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to multiple freeze and thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.
Tissue specificity	Ubiquitous. Expressed in ovarian cancers (at protein level). Expressed strongly in skeletal muscle. Expressed weakly in brain, heart, pancreas and in prostate epithelial cells.
Posttranslational modification	Phosphorylated. Phosphorylation occurs essentially on serine residues. Phosphorylation occurs in response to androgen treatment in prostate cancer cells in a mTOR-dependent manner. Phosphorylated; hyperhosphorylated in mitochondria in a mTORC-dependent signaling pathway. Phosphorylated at Ser-372 by RPS6KB1 in a growth factor- and rapamycin-dependent manner. S6K1-mediated mitochondrial phosphorylation at Ser-372 disrupts the URI1-PPP1CC complex in the mitochondrion, relieves PPP1CC phosphatase inhibition activity and hence engages a negative feedback diminishing RPS6KB1 kinase activity, preventing sustained S6K1-dependent signaling.
Celluar localization	Cytosol;Mitochondrion;Nucleus;
UniPort	O94763