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Rabbit Anti-RANBP1 Polyclonal Antibody#abs137854

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Description

Catalog-specification	Delivery time	USD price
abs137854-100ug	1-2 Weeks	301.0
abs137854-50ug	1-2 Weeks	201.0

Overview
catalog	abs137854
Other names	Ran binding protein 1, also known as RANBP1 or Ran-specific GTPase activating protein, is a crucial protein involved in various cellular processes. This protein plays a significant role in the regulation of Ran GTPase activity. The RANBP1 gene, which encodes this protein, is found in humans. Ran binding protein 1, or RANBP1, is a protein that interacts with Ran GTPase and helps in its regulation. By acting as a GTPase activating protein for Ran, RANBP1 plays a crucial role in the control of nucleocytoplasmic transport, cell cycle progression, and mitotic spindle assembly. The RANBP1 gene encodes the RANBP1 protein, which consists of multiple domains. These domains allow RANBP1 to interact with other proteins and molecules in the cell. One such domain is the Ran-binding domain (RBD), which enables RANBP1 to bind specifically to Ran. RANBP1 is involved in the transport of proteins and RNA molecules between the nucleus and the cytoplasm. It acts as a regulator of the Ran GTPase cycle, which is essential for this transport process. By promoting the hydrolysis of GTP to GDP, RANBP1 inactivates Ran and facilitates the release of cargo molecules from Ran-GTP complexes. Moreover, RANBP1 is essential for proper cell division, as it participates in mitotic spindle assembly and regulation. It interacts with other proteins involved in spindle formation, ensuring the accurate segregation of chromosomes during cell division. In summary, RANBP1 is a critical protein that regulates Ran GTPase activity and plays diverse roles in nucleocytoplasmic transport and cell division processes. Its interactions with other molecules and proteins make it an indispensable factor in maintaining cellular homeostasis.
Source	Rabbit
Specificity	The endogenous levels of total RANBP1 can be accurately detected by the RANBP1 Antibody. By rearranging the provided information, a highly similar content can be generated.
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Bovine;Dog
Antigen	RANBP1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human RANBP1.
MW	23 kDa
Properties
Concentration	1mg/ml
purification	Utilizing the SulfoLink™ Coupling Resin, the antiserum underwent peptide affinity chromatography purification. To ensure a highly specific and effective purification process, this methodology was employed.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the integrity of the product, it is recommended to store it at a temperature of -20 °C for up to one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles, as this can compromise its quality.
Storage buffer	This product contains Rabbit IgG in a buffer solution containing phosphate and saline, with a pH of 7.4. It also contains 150mM NaCl, 0.02% sodium azide, and is stabilized with 50% glycerol. The recommended storage temperature is -20 °C, and the product is stable for up to 12 months from the receipt date.
Target
Background	Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.
Celluar localization	Cytoskeleton;Cytosol;Nucleus;
UniPort	P43487