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Rabbit Anti-PRG2 Polyclonal Antibody#abs136512

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Description

Catalog-specification	Delivery time	USD price
abs136512-100ug	1-2 Weeks	301.0
abs136512-50ug	1-2 Weeks	201.0

Overview
catalog	abs136512
Description	The gene in question is responsible for producing the primary component of the crystalline core in eosinophil granules. While occurring in high levels in placenta and pregnancy serum, the proform of this protein combines with other proteins such as pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. It's suggested that this protein may function as a cytotoxin and helminthotoxin in antiparasitic defense mechanisms while also playing a role in immune hypersensitivity reactions. Additionally, it has been directly connected to epithelial cell damage, bronchospasm, and exfoliation in allergic diseases. Multiple variants of this protein are generated by alternative splicing, producing different isoforms.
Other names	Proteoglycan 2, also known as BMPG or bone marrow proteoglycan, is a protein that plays an essential role in various physiological processes. It is encoded by the PRG2 gene and is also referred to as PRG2 or EMBP. Additionally, proteoglycan 2 is associated with pregnancy and is sometimes called pregnancy-associated major basic protein. This protein can also activate natural killer cells and is known as a major basic protein, or MBP1. Eosinophil granule major basic protein, or Eosinophil major basic protein, is another name for proteoglycan 2. It is found in eosinophil granules and has been linked to allergic reactions and asthma. Despite its many names, proteoglycan 2 remains a crucial protein with significant implications for human health. Its intricate structure and complex functions make it a fascination for scientists and medical professionals alike.
Source	Rabbit
Specificity	The total PRG2 levels in the body are detected using the PRG2 Antibody, which specifically targets the endogenous PRG2 protein. To ensure accurate detection, the antibody has been designed to recognize and bind to the total PRG2 present in the biological samples. By utilizing this antibody, researchers can effectively assess the levels of total PRG2 and investigate its role in various biological processes.
Species Reactivity	Human;Mouse
Antigen	PRG2
Application	：，。，1:500-1:2000；（IHC），1:50-1:200；（ELISA），1:20000-1:40000。，。
Immunogen	A synthesized peptide derived from human PRG2.
MW	25kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
Tissue specificity	High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon.
Posttranslational modification	Nitrated.
Celluar localization	Extracellular region or secreted;
UniPort	P13727