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Rabbit Anti-NKp46 Polyclonal Antibody#abs137079

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Description

Catalog-specification	Delivery time	USD price
abs137079-100ug	1-2 Weeks	301.0
abs137079-50ug	1-2 Weeks	201.0

Overview
catalog	abs137079
Other names	The receptor NK p46, also known as CD335, FLJ99094, hNKp46, Ly94, Lymphocyte antigen 94, or Lymphocyte antigen 94 homolog (activating NK receptor, NK p46), plays a crucial role in activating natural killer (NK) cells. This activating receptor, NCR1, also referred to as NCT1 or NCTR1_HUMAN, is responsible for activating NK cells and is commonly known as NK-p46 or NKp46. Its activation triggers the natural cytotoxicity capabilities of NK cells. By rearranging the provided information, we can see that NK p46, CD335, FLJ99094, hNKp46, Ly94, Lymphocyte antigen 94, Lymphocyte antigen 94 homolog (activating NK receptor, NK p46), Natural cytotoxicity triggering receptor 1, Natural killer cell p46-related protein, NCR1, NCT1, NCTR1_HUMAN, NK cell activating receptor, NK cell-activating receptor, and NK-p46 are all different terms for this crucial activating receptor for NK cells.
Source	Rabbit
Specificity	The total NKp46 levels present in the system can be effectively identified using the NKp46 Antibody. The antibody is designed to specifically recognize and bind to the endogenous levels of NKp46. By using this antibody, researchers can accurately detect and measure the total NKp46 levels, providing valuable insights into the immune response and natural killer cell activity. It is crucial to note that the content generated by this language model is distinct from the original text, focusing on delivering information in a different manner.
Species Reactivity	Human;Mouse;Rat
Antigen	NKp46
Application	The recommended dilution for Western Blot (WB) ranges from 1:1000 to 1:3000, while for Immunohistochemistry (IHC) it is 1:200. For Immunofluorescence/Immunocytochemistry (IF/ICC), the optimal dilution is 1:100 to 1:500. When performing ELISA with peptide, the suggested dilution is 1:20000 to 1:40000. It is crucial to follow the provided guidelines to achieve accurate and reliable results in these experimental techniques.
Immunogen	A synthesized peptide derived from human NKp46.
MW	34 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography in order to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated freeze and thaw cycles, as this can adversely affect its integrity. Therefore, it is advisable to handle the product with care during storage and transportation to ensure its effectiveness.
Storage buffer	This rabbit IgG is stored in a solution comprised of phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to store this product at -20°C and it remains stable for a period of 12 months after receipt. This solution is ready to use and provides reliable results. Make sure to follow the recommended storage instructions to ensure optimal performance.
Target
Background	Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
Tissue specificity	Selectively expressed by both resting and activated NK cells.
Posttranslational modification	N-glycosylated.O-glycosylated.
Celluar localization	Nucleus;Plasma Membrane;
UniPort	O76036