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Rabbit Anti-NEIL2 Polyclonal Antibody#abs139019

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Description

Catalog-specification	Delivery time	USD price
abs139019-100ug	1-2 Weeks	301.0
abs139019-50ug	1-2 Weeks	201.0

Overview
catalog	abs139019
Other names	Neil2 is a DNA glycosylase/AP lyase enzyme that plays a key role in DNA repair. It functions by recognizing and removing damaged DNA bases, specifically apurinic or apyrimidinic sites. Neil2 is also referred to as DNA-(apurinic or apyrimidinic site) lyase Neil2 or Endonuclease 8-like 2. Furthermore, Neil2, also known as Endonuclease VIII-like 2 or NEH2, is a homolog of the Nei endonuclease VIII enzyme found in E. coli. Its primary function is to cleave DNA at sites with oxidative damage, facilitating the repair process. The NEIL2 gene encodes for this particular enzyme. NEIL2, or Nei-like 2, is an essential protein involved in maintaining the integrity of the genome. Its activity helps to prevent the accumulation of mutations and the development of various diseases associated with DNA damage. The NEIL2 protein exhibits characteristics similar to the Nei endonuclease VIII. In summary, NEIL2, also denoted as NEIL2_HUMAN, is a DNA glycosylase/AP lyase enzyme essential for DNA repair. It acts as an endonuclease, cleaving DNA at damaged sites such as apurinic or apyrimidinic sites. NEIL2 shares similarities with the Nei endonuclease VIII enzyme found in E. coli. Its function is crucial in maintaining genome integrity and preventing the occurrence of DNA damage-related diseases.
Source	Rabbit
Specificity	The NEIL2 Antibody is capable of identifying the total NEIL2 present in the body at its natural levels. Let's create a highly similar content by rearranging the information from the original text: Detection of total NEIL2 at its endogenous levels is made possible through the application of the NEIL2 Antibody.
Species Reactivity	Human;Mouse
Predictive reaction species	Rabbit;Sheep;Dog;Horse;Bovine
Antigen	NEIL2
Application	The dilution recommendation for WB is 1:1000-3000, while for IHC it is 1:200. When it comes to ELISA using peptides, the suggested dilution is 1:20000-1:40000. These recommendations are based on the original text information and should be followed for optimal results.
Immunogen	A synthesized peptide derived from human NEIL2.
MW	37 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended that you store it in a freezer at -20 °C for up to one year. It is important to avoid exposing the product to repeated cycles of freezing and thawing, as this could compromise its efficacy. Please make sure to follow these guidelines to ensure the longevity and effectiveness of the product.
Storage buffer	This product consists of Rabbit IgG dissolved in phosphate buffered saline, with a pH of 7.4, along with 150mM NaCl, 0.02% sodium azide and 50% glycerol. This product should be stored at -20°C and is stable for a period of 12 months from the date of receipt. Please ensure that you store this product in the correct conditions to ensure its effectiveness. Thank you for choosing our product!
Target
Background	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
Tissue specificity	Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver.
Celluar localization	Cytoskeleton;Nucleus;
UniPort	Q969S2