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Rabbit Anti-NCOR2 Polyclonal Antibody#abs138416

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Description

Catalog-specification	Delivery time	USD price
abs138416-100ug	1-2 Weeks	301.0
abs138416-50ug	1-2 Weeks	201.0

Overview
catalog	abs138416
Other names	Nuclear receptor co-repressor 2, also known as N-CoR2 or CTG26, is a protein that plays a critical role in gene expression regulation. It is a member of the SMRT/N-CoR family of transcriptional coregulators and is a key component of the repressive machinery that regulates the activity of nuclear hormone receptors. N-CoR2 acts as a silencing mediator for retinoid and thyroid hormone receptors, and is essential for the proper functioning of these receptors. It is also involved in the regulation of other transcription factors and signaling pathways. TNRC14 or TRAC1, also referred to as CTG26, is part of the SMRT/N-CoR family of transcriptional coregulators. It has been shown to associate with thyroid and retinoic acid receptors and function as a co-repressor for these receptors. The protein is involved in the regulation of gene expression and plays a critical role in development and differentiation. Its role in other cellular processes and signaling pathways is still under investigation. SMRTE tau, which is a member of the SMRT/N-CoR family, is another variant of the N-CoR2 protein. SMAP270 is a shorter name for N-CoR2 protein, as the full name is quite long. The CTG repeat protein 26 or CTG26 is also known as Ncor2, which is a synonym of N-CoR2.
Source	Rabbit
Specificity	The NCOR2 Antibody is capable of recognizing the total NCOR2 protein at its natural expression levels in cells. For discerning the presence of endogenous NCOR2, this antibody proves to be highly effective. Its ability to detect and bind to NCOR2 allows for accurate and reliable analysis of its expression in biological samples. By leveraging the specificity and sensitivity of the NCOR2 Antibody, researchers can gain invaluable insights into the roles and functions of this protein in various physiological and pathological processes.
Species Reactivity	Human
Predictive reaction species	Chicken;Pig;Sheep;Bovine;Horse
Antigen	NCOR2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human NCOR2.
MW	274 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was employed for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to keep the product at a temperature of -20 °C for up to one year. It is crucial to avoid exposing the product to repeated cycles of freezing and thawing. This step will help maintain the integrity and efficacy of the product, ensuring it delivers the expected results when used. Always follow the recommended storage guidelines to prolong the shelf life of the product.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival.
Tissue specificity	Ubiquitous. High levels of expression are detected in lung, spleen and brain.
Celluar localization	Nucleus;
UniPort	Q9Y618