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Rabbit Anti-MYOCD Polyclonal Antibody#abs132813

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Description

Catalog-specification	Delivery time	USD price
abs132813-100ug	1-2 Weeks	301.0
abs132813-50ug	1-2 Weeks	201.0

Overview
catalog	abs132813
Description	This transcriptional factor relies on the classic CArG box DNA sequence, whether it is single or multiple. It has a specialized ability to bind to CArG boxes when SRF is present. As a partner of SRF, it helps to regulate the expression of certain genes that are associated with cardiac and smooth muscle tissues. This factor is critical in the process of cardiogenesis and the evolution of the smooth muscle cell lineage. Its important role in modulating SRF-target genes makes it an essential component in the development of these muscle tissues.
Other names	MYCD; MYCD_HUMAN; Myocardin; Myocd;
Source	Rabbit
Specificity	The MYOCD antibody is capable of detecting total MYOCD levels present in the body naturally. With this information, researchers can analyze the expression of MYOCD in various biological systems and study the role of this protein in different physiological processes. It is an essential tool for investigating the functions and mechanisms of MYOCD in health and disease.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Chicken;
Antigen	MYOCD
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	100 kDa
Properties
Concentration	1mg/ml
purification	By utilizing SulfoLink™ Coupling Resin, the antiserum was effectively purified through peptide affinity chromatography. This process enabled the isolation and removal of impurities, leaving behind a highly purified and concentrated antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	The recommended storage condition is -20 °C for a duration of one year, while it is important to prevent the product from undergoing multiple freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity).
Tissue specificity	Expressed in heart, aorta, and in smooth muscle cell-containing tissues: stomach, bladder, small intestine, colon, lung, placenta and uterus. Very faint expression in prostate and skeletal muscle.
Posttranslational modification	Phosphorylation regulates negatively the intrinsic myocardin transcriptional activity.
Celluar localization	Nucleus;
UniPort	Q8IZQ8