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Rabbit Anti-MLTK Polyclonal Antibody#abs133756

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Description

Catalog-specification	Delivery time	USD price
abs133756-100ug	1-2 Weeks	301.0
abs133756-50ug	1-2 Weeks	201.0

Overview
catalog	abs133756
Other names	Leucine zipper and sterile alpha motif containing kinase, also known as AZK or MLK7, is a protein that plays a crucial role in suppressing cervical cancer. It belongs to the family of mitogen-activated protein kinase kinase kinases and is associated with HCCS-4 or HCCS4. AZK is characterized by its leucine zipper and sterile alpha motif, which contribute to its kinase activity and regulate its function. The involvement of AZK in cervical cancer makes it an important target for research and potential therapeutic interventions. Its role as a cervical cancer suppressor gene has raised interest in understanding its mechanism of action and exploring its potential as a target for drug development. Furthermore, AZK is part of the mixed lineage kinase-related kinase family, which includes MLT and MRK beta. These kinases share structural and functional similarities with AZK and are involved in various cellular processes, including cell growth, differentiation, and apoptosis. Overall, the discovery of AZK and its association with cervical cancer highlight the complex nature of this disease and the need for further investigation to develop effective treatments.
Source	Rabbit
Specificity	The MLTK Antibody is capable of detecting total MLTK present in the body at its natural levels.
Species Reactivity	Human;Mouse
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Bovine;Sheep;
Antigen	MLTK
Application	For Western blotting, a dilution of 1:500 to 1:1000 is recommended. When performing immunofluorescence or immunocytochemistry, a dilution of 1:100 to 1:500 is ideal. For ELISA assays using peptides as the antigen, a dilution of 1:20000 to 1:40000 is recommended. It is important to follow these guidelines for optimal results in your experiments.
Immunogen	A synthesized peptide.
MW	91 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the purification of the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636).
Tissue specificity	Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.
Celluar localization	Cytosol;Nucleus;
UniPort	Q9NYL2