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Rabbit Anti-Mitofusin Polyclonal Antibody#abs137029

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Description

Catalog-specification	Delivery time	USD price
abs137029-100ug	1-2 Weeks	301.0
abs137029-50ug	1-2 Weeks	201.0

Overview
catalog	abs137029
Other names	Fzo homolog is a protein that plays a crucial role in mitochondrial function. It is also known as Hfzo1, Hfzo2, or MFN 1. These different names reflect variations in the nomenclature used to describe this protein. MFN1, also referred to as Mitochondrial Transmembrane GTPase Fzo1 or Mitofusin 1, is the human form of this protein. It is responsible for the fusion of mitochondria, a process essential for maintaining mitochondrial integrity and proper cellular function. The MFN1 gene encodes the Mitofusin-1 protein, which is part of the transmembrane GTPase family. Additionally, another isoform, Mitochondrial Transmembrane GTPase FZO2, also known as MFN1B, is involved in similar functions. The protein MFN1 has been studied extensively and is of significant interest due to its importance in mitochondrial dynamics and its potential relevance to various diseases.
Source	Rabbit
Specificity	The Mitofusin Antibody is capable of detecting the total amount of Mitofusin present in the body. This means that it can identify the endogenous levels of this protein in a sample. If you need to determine the amount of Mitofusin in a specific tissue or cell type, this antibody is a reliable tool for doing so. By detecting the total amount of Mitofusin, you can gain insight into the function and activity of this important protein in various physiological processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Pig;
Antigen	Mitofusin
Application	，：，WB（Western Blotting），1:10001:3000。IHC（），1:200。ELISA（），1:200001:40000。。。
Immunogen	A peptide synthesized from human Mitofusin is available. Let's create a content closely resembling the original text by rearranging the information provided.
MW	84 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was achieved through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is advised to store it at a temperature of -20°C for up to a year. It is important to avoid subjecting the product to multiple freeze and thaw cycles, as this could compromise its integrity.
Storage buffer	This solution contains Rabbit IgG in a buffer of phosphate saline with a pH of 7.4, 150mM NaCl, and 0.02% sodium azide. Additionally, it is supplemented with 50% glycerol for storage at -20°C, allowing for stability up to 12 months from the date of receipt. It is essential to follow the storage instructions to ensure optimal functionality of the product.
Target
Background	Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303).
Tissue specificity	Detected in kidney and heart (at protein level) (PubMed:12759376). Ubiquitous (PubMed:11950885, PubMed:12759376). Expressed at slightly higher level in kidney and heart (PubMed:12759376). Isoform 2 may be overexpressed in some tumors, such as lung cancers (PubMed:11751411).
Posttranslational modification	Ubiquitinated by non-degradative ubiquitin by PRKN (PubMed:23933751). Deubiquitination by USP30 inhibits mitochondrial fusion (By similarity). Ubiquitinated by MARCH5 (PubMed:20103533). When mitochondria are depolarized and dysfunctional, it is ubiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that contains FBXO7 and PRKN (PubMed:23933751).
Celluar localization	Mitochondrion;
UniPort	Q8IWA4