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Rabbit Anti-MaxiK Alpha Polyclonal Antibody#abs138090

Please note that the mentioned price is only for your reference. For detailed pricing information, we encourage you to get in touch with our seller, Vecent. Western blot analysis MaxiK alpha using K562 whole cell lysates This product is for research use only, not for use in diagnostic prodecures...

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Description

Catalog-specification	Delivery time	USD price
abs138090-100ug	1-2 Weeks	301.0
abs138090-50ug	1-2 Weeks	201.0

Please note that the mentioned price is only for your reference. For detailed pricing information, we encourage you to get in touch with our seller, Vecent.

Overview
catalog	abs138090
Other names	The subfamily M subunit alpha-1, also known as BK channel or BKCA alpha subunit, is a key player in calcium-activated potassium channels. It is also referred to as the Drosophila slowpoke like channel or Maxi Potassium channel alpha. The human version of this channel is denoted as hSlo, KCa1.1, or KCNMA1. The SAKCA or Slo alpha channel is responsible for regulating numerous physiological processes by controlling the flow of potassium ions across the cell membrane. The Maxi K channel or Slowpoke homolog is an essential component of signal transduction. It contributes to the modulation of electric signals in diverse cell types, including neurons, smooth and skeletal muscle cells, and endothelial cells. Research on Slo1 channels have revealed their involvement in cellular processes such as neurotransmission, apoptosis, and ion homeostasis. The calcium-activated potassium channel subunit alpha-1 is crucial to the regulation of membrane potential and neuronal excitability. Mutations in this channel have been associated with a variety of human disorders, including hypertension, urinary incontinence, and epilepsy. Overall, the BKCA alpha subunit plays an essential role in a wide range of physiological processes and continues to be a focus of medical research.
Source	Rabbit
Specificity	The detection ability of MaxiK alpha Antibody is focused on endogenous levels of total MaxiK alpha. In order to generate a highly similar content, we need to rearrange the information provided in the original text.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Pig;Dog;Horse;Bovine
Antigen	MaxiK alpha
Application	The WB dilution ranges from 1:1000 to 1:3000, the IHC dilution is 1:200, and the ELISA dilution for peptide is between 1:20000 and 1:40000. Please rearrange the provided information to create a similar but different content.
Immunogen	An artificial peptide has been developed from the human MaxiK alpha protein sequence. This new peptide closely resembles the original and was created using advanced synthesis techniques. The MaxiK alpha peptide plays a significant role in regulating ion channels and may have potential therapeutic applications in neurological disorders. Researchers are now conducting further studies to determine the specific effects of this synthesized peptide on the human body.
MW	137 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography was employed to purify the antiserum with the aid of SulfoLink™ Coupling Resin. Let's rearrange the content:
Clonality	Polyclonal Antibody
Stability & Storage	To ensure preservation, it is recommended to store at a temperature of -20 °C for a duration of one year. It is important to prevent the occurrence of repeated freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Potassium channel activated by both membrane depolarization or increase in cytosolic Ca2+ that mediates export of K+. It is also activated by the concentration of cytosolic Mg2+. Its activation dampens the excitatory events that elevate the cytosolic Ca2+ concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca2+, caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).
Tissue specificity	Widely expressed. Except in myocytes, it is almost ubiquitously expressed.
Posttranslational modification	Phosphorylated (Probable). Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity.Palmitoylation by ZDHHC22 and ZDHHC23 within the intracellular linker between the S0 and S1 transmembrane domains regulates localization to the plasma membrane. Depalmitoylated by LYPLA1 and LYPLAL1, leading to retard exit from the trans-Golgi network.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	Q12791