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Rabbit Anti-LAT Polyclonal Antibody#abs137107

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Description

Catalog-specification	Delivery time	USD price
abs137107-100ug	1-2 Weeks	301.0
abs137107-50ug	1-2 Weeks	201.0

Overview
catalog	abs137107
Other names	This protein is known by several names, including 36 kDa phospho-tyrosine adapter protein, 36 kDa phospho-tyrosine adaptor protein, and LAT 1. It is also sometimes referred to as Linker for activation of T cells or Linker for activation of T cells family member 1. This transmembrane adaptor protein plays an important role in the activation of T cells and is often abbreviated as LAT. It is also sometimes called p36 38 or pp36. Despite the various names, they all refer to the same protein and its crucial role in modulating immune responses.
Source	Rabbit
Specificity	Total LAT can be detected using the LAT Antibody, which is designed to specifically target and recognize endogenous levels of LAT.
Species Reactivity	Human;Mouse
Antigen	LAT
Application	WB1:1000-3000，IF/ICC1:200-1:500，ELISA（）1:20000-1:40000。，。
Immunogen	A synthesized peptide derived from human LAT.
MW	28kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was accomplished through peptide affinity chromatography. It is crucial to rearrange the original text information while generating highly similar content.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve its quality, it is recommended to store the product at -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing.
Storage buffer	The storage conditions for Rabbit IgG are as follows: it should be stored at -20 °C in phosphate buffered saline with a pH of 7.4 and concentrations of 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The stability of the IgG is guaranteed for 12 months starting from the date of receipt.
Target
Background	Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
Tissue specificity	Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).
Posttranslational modification	Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Phosphorylated by ITK leading to the recruitment of VAV1 to LAT-containing complexes.Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.
Celluar localization	Lysosome;Nucleus;Plasma Membrane;
UniPort	O43561