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Rabbit Anti-JTB Polyclonal Antibody#abs138190

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Description

Catalog-specification	Delivery time	USD price
abs138190-100ug	1-2 Weeks	301.0
abs138190-50ug	1-2 Weeks	201.0

Overview
catalog	abs138190
Other names	Prostate androgen regulated protein, also known as PAR protein or jumping translocation breakpoint (JTB), plays a significant role in various biological processes. Its corresponding gene, JTB_HUMAN, codes for the protein JTB or Jumping translocation breakpoint protein. HJT, HJTB, and HSPC222 are other aliases for this protein. JTB_HUMAN is involved in the regulation of androgen receptors in the prostate gland. It is an androgen-regulated protein that responds to androgen signaling in this tissue. The exact function of JTB_HUMAN is still being investigated, but it is believed to contribute to prostate development and function. Furthermore, JTB_HUMAN is associated with a chromosomal rearrangement called jumping translocation breakpoint, which is characterized by the translocation of genetic material between different chromosomes. This rearrangement can lead to abnormal gene expression and is implicated in the development of certain diseases. Due to the importance of JTB_HUMAN and its association with prostate function and genetic rearrangements, further research is being conducted to elucidate its exact role in cellular processes. Understanding the functions of JTB_HUMAN and its related proteins could potentially provide valuable insights into disease mechanisms and therapeutic interventions.
Source	Rabbit
Specificity	Endogenous levels of total JTB can be detected using the JTB Antibody.
Species Reactivity	Human
Predictive reaction species	Pig;Rabbit;
Antigen	JTB
Application	，： ELISA(peptide)：1:20000-1:40000，IF/ICC：1:100-1:500，WB：1:1000-3000。
Immunogen	A synthesized peptide derived from human JTB.
MW	16 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography was employed to purify the antiserum through the use of SulfoLink™ Coupling Resin.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the product's quality, it is recommended to keep it at a temperature of -20°C for a period of one year. It is advisable to avoid frequent thawing and freezing of the product to prevent damage.
Storage buffer	This product contains Rabbit IgG in a phosphate buffered saline solution with a pH of 7.4, 150mM NaCl, and 0.02% sodium azide. It also contains 50% glycerol and should be stored at -20°C for optimal stability. This solution will remain stable for up to 12 months from the date of receipt. Please ensure proper storage and handling procedures to maintain the integrity of the product.
Target
Background	Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
Tissue specificity	Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts.
Celluar localization	Cytoskeleton;Mitochondrion;Plasma Membrane;
UniPort	O76095