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Rabbit Anti-IBTK Polyclonal Antibody#abs138401

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Description

Catalog-specification	Delivery time	USD price
abs138401-100ug	1-2 Weeks	301.0
abs138401-50ug	1-2 Weeks	201.0

Overview
catalog	abs138401
Other names	BTKI, also known as inhibitor of Bruton agammaglobulinemia tyrosine kinase or IBtk, is a protein that plays a crucial role in suppressing the activity of Bruton tyrosine kinase (BTK). As its name suggests, BTKI acts as an inhibitor of BTK, a key enzyme involved in B-cell signaling and development. By binding to BTK and preventing its activation, BTKI regulates immune cell functions and helps maintain normal immune responses. In humans, the IBTK gene encodes the BTKI protein, which is widely expressed in various tissues. Dysregulation of BTKI expression has been implicated in several diseases, including cancer and autoimmune disorders. Understanding the molecular mechanisms of BTKI and its interactions with BTK may provide insights into the development of novel therapies for these diseases.
Source	Rabbit
Specificity	The antibody IBTK detects the total endogenous levels of IBTK.
Species Reactivity	Human
Predictive reaction species	Dog
Antigen	IBTK
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human IBTK.
MW	151kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, peptide affinity chromatography was employed to purify the antiserum. A highly similar content can be generated by reordering the original text information as follows.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure product quality, it is recommended to store at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	This product contains Rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4 and 150mM NaCl. It also includes 0.02% sodium azide and 50% glycerol as stabilizing agents. This product should be stored at a temperature of -20 °C for maximum stability, and is safe for use for up to 12 months from the date of receipt. Please follow all provided instructions carefully to ensure optimal performance and longevity of this product.
Target
Background	Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription.
Tissue specificity	Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues.
Celluar localization	Nucleus;
UniPort	Q9P2D0