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Rabbit Anti-GCFC1 Polyclonal Antibody#abs139049

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Description

Catalog-specification	Delivery time	USD price
abs139049-100ug	1-2 Weeks	301.0
abs139049-50ug	1-2 Weeks	201.0

Overview
catalog	abs139049
Other names	GCFC1 (Chromosome 21 open reading frame 66) is an intriguing protein with diverse roles. Also known as FSAP105 (Functional spliceosome-associated protein 105), GCFC1 is a GC-rich sequence DNA binding factor candidate. It exhibits vital functions in multiple biological processes and is involved in various cellular activities. This highly versatile protein, GCFC1, is referred to as PAX3 and PAX7 binding protein 1 or PAXBP1. Its interactions with PAX proteins have garnered significant attention in the scientific community. The precise mechanisms and implications of these interactions are still under investigation, but it is believed that GCFC1 plays an important role in modulating the activities of PAX3 and PAX7. GCFC1 has been found to possess a DNA-binding domain that preferentially recognizes GC-rich DNA sequences. This property suggests its crucial role in regulating gene expression by binding to specific genomic regions. The existence of this GC-rich sequence DNA-binding factor highlights GCFC1 as a potential transcriptional regulator in various cellular contexts. The significance of GCFC1 extends beyond its DNA-binding capabilities. It is an integral component of the spliceosome, a complex molecular machinery essential for pre-mRNA processing. Through its association with the spliceosome, GCFC1 plays a crucial role in ensuring accurate and efficient mRNA splicing. Dysregulation of this process can have profound consequences on gene expression and cellular function. In summary, GCFC1 is a multifunctional protein with a wide range of roles. Its DNA-binding ability, association with the spliceosome, and interactions with PAX proteins make it a crucial player in gene regulation and cellular processes. Further research is needed to fully elucidate the intricate mechanisms and functional implications of GCFC1 in various biological contexts.
Source	Rabbit
Specificity	The GCFC1 antibody has the ability to recognize and bind to total GCFC1 levels present within the body. This binding occurs without any external interference and is purely based on the internal structure of GCFC1. As a result, GCFC1 antibody is able to serve as an effective tool for the detection of endogenous GCFC1 levels, allowing researchers to study and analyze its role in various biological processes.
Species Reactivity	Human;Mouse
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	GCFC1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human GCFC1.
MW	105 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it should be stored at a temperature of -20 °C for a period of one year. It is important to prevent the product from being exposed to repeated freeze and thaw cycles as it might cause damage and affect its effectiveness. Thus, it is crucial to handle the product with care and follow the recommended storage instructions.
Storage buffer	The Rabbit IgG is present in a solution of phosphate buffered saline with a pH of 7.4. Along with 150mM NaCl, the solution also contains 0.02% sodium azide and 50% glycerol, which helps stabilize the contents. To ensure the longevity of the solution, storage at -20°C is recommended, and it is stable for up to 12 months from the date of receipt.
Target
Background	Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity).
Tissue specificity	Ubiquitous.
Celluar localization	Cytosol;Nucleus;
UniPort	Q9Y5B6