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Rabbit Anti-FOLR3 Polyclonal Antibody#abs139039

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Description

Catalog-specification	Delivery time	USD price
abs139039-100ug	1-2 Weeks	301.0
abs139039-50ug	1-2 Weeks	201.0

Overview
catalog	abs139039
Other names	Folate receptor gamma, also known as folate receptor 3 or FR G, is an important protein involved in folate transport. It plays a key role in the uptake of folate from the bloodstream into cells. Folate is a B-vitamin that is essential for numerous biological processes, including DNA synthesis and cell division. Folate receptor gamma is specifically expressed in certain tissues and cells and has a high affinity for folate. This receptor is important for the delivery of folate to cells where it is needed for various cellular functions. The expression of folate receptor gamma is regulated in a tissue-specific manner and its dysfunction has been implicated in various diseases, including cancer. Understanding the role and regulation of folate receptor gamma provides valuable insights into the biology of folate metabolism and potential therapeutic targets.
Source	Rabbit
Specificity	The detection of endogenous levels of total FOLR3 can be accomplished using the FOLR3 Antibody. This antibody is designed to specifically target and recognize FOLR3 in biological samples. By using this antibody, researchers can determine the expression levels of FOLR3 in various tissues and cell types. This information is valuable for studying the role of FOLR3 in different physiological and pathological conditions.
Species Reactivity	Human
Antigen	FOLR3
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human FOLR3.
MW	28 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, peptide affinity chromatography was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality, store it at -20 °C for one year, and make sure to avoid any freeze/thaw cycles. It is crucial to follow these guidelines for optimal storage conditions.
Storage buffer	This product consists of Rabbit immunoglobulin G (IgG) diluted in phosphate buffered saline (PBS), with a pH of 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. It should be stored at -20°C and is stable for up to 12 months from the date of receipt.
Target
Background	The transport protein has the ability to bind folate and its derived forms such as reduced folic acid, facilitating the transport of 5-methyltetrahydrofolate into cells. It is important to note that the Short isoform lacks the ability to bind folate. To reiterate, the protein enables the delivery of 5-methyltetrahydrofolate into the interior of cells by binding to folate and reduced folic acid derivatives.
Tissue specificity	Spleen, thymus, bone marrow, ovarian carcinoma, and uterine carcinoma.
Celluar localization	Extracellular region or secreted;
UniPort	P41439