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Rabbit Anti-CCT5 Polyclonal Antibody#abs134861

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Description

Catalog-specification	Delivery time	USD price
abs134861-100ug	1-2 Weeks	301.0
abs134861-50ug	1-2 Weeks	201.0

Overview
catalog	abs134861
Other names	Chaperonin containing TCP1 subunit 5 epsilon, also known as CCT5 or CCTE, is a protein that plays a crucial role in cellular processes. It is encoded by the KIAA0098 gene and is a subunit of the chaperonin-containing T-complex polypeptide 1 complex. This protein is involved in the folding and assembly of other proteins, ensuring their proper structure and function. The TCP1 epsilon subunit works in collaboration with other subunits to form a chaperonin cage, where newly synthesized proteins enter and undergo folding. The chaperonin-containing TCP1 subunit 5 epsilon is essential for maintaining cellular homeostasis and preventing protein misfolding. Its dysfunction has been associated with various diseases related to protein aggregation and cellular stress. Understanding the role of CCT5 in protein folding may provide insights into the development of therapeutic strategies for proteinopathies and other protein misfolding diseases.
Source	Rabbit
Specificity	Total CCT5 levels can be detected by the CCT5 Antibody, which specifically targets the endogenous levels of this protein.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Dog;Horse
Antigen	CCT5
Application	The dilution range for Western Blot (WB) is 1:500 to 1:1000, for Immunofluorescence/Immunocytochemistry (IF/ICC) is 1:100 to 1:500, and for ELISA (peptide) is 1:20000 to 1:40000. Please note that the generated content will not follow the same pattern as the original text, as it will be generated using a language model.
Immunogen	A synthesized peptide.
MW	67 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. It was a thorough process that resulted in a highly purified antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, store it for one year at a temperature of -20 °C. Be careful to prevent any freeze/thaw cycles from occurring.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
Tissue specificity	Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).
Celluar localization	Cytoskeleton;Cytosol;Extracellular region or secreted;Nucleus;
UniPort	P48643