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Rabbit Anti-AVPR1A Polyclonal Antibody#abs137871

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Description

Catalog-specification	Delivery time	USD price
abs137871-100ug	1-2 Weeks	301.0
abs137871-50ug	1-2 Weeks	201.0

Overview
catalog	abs137871
Other names	AVPR 1A, also known as antidiuretic hormone receptor 1a or arginine vasopressin receptor 1A, is a receptor protein involved in the regulation of water balance and blood pressure in the body. It is encoded by the AVPR1A gene and is also referred to as AVPR 1, AVPR1, AVPR V1a, or V1a vasopressin receptor. The AVPR 1A receptor is primarily found in the liver and blood vessels, hence its alternative names - vascular/hepatic type arginine vasopressin receptor or V1 vascular vasopressin receptor. Its main function is to bind with the arginine vasopressin hormone, also known as vasopressin or ADH, and mediate its physiological effects. The AVPR 1A receptor plays a crucial role in regulating water reabsorption in the kidneys, reducing urine production, and increasing water retention in the body. This helps maintain proper fluid balance and prevents excessive water loss. Additionally, it also acts as a vasoconstrictor, meaning it narrows blood vessels, thus increasing blood pressure. Disruptions in the AVPR 1A receptor function can lead to various health conditions. For instance, mutations in the AVPR1A gene have been associated with disorders such as nephrogenic diabetes insipidus, which is characterized by an inability of the kidneys to respond to the antidiuretic effects of vasopressin. In summary, the AVPR 1A receptor, also known as the V1a vasopressin receptor, is a key component in the regulation of water balance and blood pressure in the body. Its presence in the liver and blood vessels highlights its role in these specific physiological processes. Understanding the functions and mechanisms of this receptor provides valuable insights into various conditions related to water balance and blood pressure regulation.
Source	Rabbit
Specificity	The total AVPR1A levels are detected by the AVPR1A Antibody, which specifically targets the endogenous expression of AVPR1A protein.
Species Reactivity	Human;Mouse
Antigen	AVPR1A
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human AVPR1A.
MW	47 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly refined product was produced after the process for a more potent and effective solution.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, store at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to repeated freeze/thaw cycles.
Storage buffer	Phosphate buffered saline (PBS) with Rabbit IgG, containing 150mM NaCl and 0.02% sodium azide, has a pH of 7.4. To ensure its preservation, it should be stored at a temperature of -20 °C. With the addition of 50% glycerol, it maintains its stability for a period of 12 months from the date of receipt.
Target
Background	Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.
Celluar localization	Endosome;Plasma Membrane;
UniPort	P37288