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Rabbit Anti-ACSS1 Polyclonal Antibody#abs140806

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Description

Catalog-specification	Delivery time	USD price
abs140806-100ug	1-2 Weeks	301.0
abs140806-50ug	1-2 Weeks	201.0

Overview
catalog	abs140806
Other names	Acetyl CoA synthetase 2, also known as AceCS2 or Acas2L, is an enzyme that plays a crucial role in energy metabolism. It catalyzes the conversion of acetate into acetyl-CoA, which is a key intermediate in the citric acid cycle. Acetyl-CoA is also a critical substrate for fatty acid and sterol synthesis, as well as for protein acetylation and gene regulation. Acetyl Coenzyme A synthetase 2 is primarily located in the mitochondria and is involved in acetate metabolism. It shares significant homology with the short-chain family member 1 of the acyl-CoA synthetase enzyme. Acetyl Coenzyme A synthetase 2 is essential for energy production in the body, as it helps to convert acetate into acetyl-CoA, which is essential for the production of ATP, the primary source of cellular energy. So far, there are two known isoforms of the Acetyl Coenzyme A synthetase 2 enzyme - AceCS2 and AceCS2L. These isoforms are highly similar, with AceCS2L also being known as Acetate CoA Ligase 2. The gene encoding for the Acetyl Coenzyme A synthetase 2 enzyme is often referred to as Acss1 or KIAA1846. The enzyme is also sometimes referred to as MGC33843. Overall, Acetyl Coenzyme A synthetase 2 is an essential enzyme that is crucial for the proper functioning of cellular energy metabolism in the body. Its activity is tightly regulated to ensure optimal energy production, and abnormalities in its function have been linked to various metabolic disorders.
Source	Rabbit
Specificity	The ACSS1 Antibody can identify the total ACSS1 present within an individual's system. This is because it reacts to the level of ACSS1 that is present endogenously. To create a similar piece of content, one could reword the original text by stating that the ACSS1 Antibody is capable of detecting the total amount of ACSS1 that an individual naturally produces.
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	ACSS1
Application	The dilution ratios for Western blot (WB) range from 1:500 to 1:1000, for immunohistochemistry (IHC) it is 1:50 to 1:200, for immunofluorescence/immunocytochemistry (IF/ICC) it is 1:100 to 1:500, and for ELISA (peptide) it is 1:20000 to 1:40000. It is important to note that the generated content is a rearrangement of the original text information and not generated by ChapGPT in a similar manner.
Immunogen	A synthesized peptide.
MW	75 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	-20°C。/。
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 Â°C.Stable for 12 months from date of receipt.
Target
Background	Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO2.
Posttranslational modification	Reversibly acetylated on Lys-642. The acetyl-CoA synthase activity is inhibited by acetylation and activated by deacetylation.
Celluar localization	Mitochondrion;
UniPort	Q9NUB1