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Rabbit Anti-ACPP Polyclonal Antibody#abs136225

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Description

Catalog-specification	Delivery time	USD price
abs136225-100ug	1-2 Weeks	301.0
abs136225-50ug	1-2 Weeks	201.0

Overview
catalog	abs136225
Description	ACPP, also known as PAP or prostatic acid phosphatase, belongs to the histidine acid phosphatase family and is also referred to as 5'-nucleotidase and thiamine monophosphatase. This enzyme is a homodimeric glycoprotein with a subunit molecular mass of 50 kDa, and it is produced in response to androgens in the human prostate gland. Studies have indicated that ACPP is a non-specific phosphatase that is involved in the progression of prostate cancer and can inactivate LPA in human seminal plasma. ACPP contains three glycosylation sites, according to research. This antibody is specifically designed to target ACPP and can be used in various applications for research purposes. Understanding the role of ACPP in prostate cancer and its function as a phosphatase can provide insight into potential diagnostic and therapeutic strategies for this common malignancy.
Other names	Prostatic acid phosphatase, also known as PAP, is an enzyme that hydrolyzes phosphate esters. It is commonly used as a marker for prostate cancer due to its high levels in the prostate gland. PAP is also sometimes referred to as 5'-NT or 5'-nucleotidase as it can also act on nucleotides. Another related enzyme is ecto-5'-nucleotidase, which is found on the surface of many cells and also hydrolyzes nucleotides. ACP3 or acid phosphatase prostate is another name for PAP and TMPase or thiamine monophosphatase is yet another related enzyme. Both ACP3 and TMPase have similar functions to PAP, but are found in different tissues.
Source	Rabbit
Specificity	The ACPP Antibody is capable of detecting the total ACPP present in the body at its natural levels. This means that it can help in the identification of any abnormalities or imbalances in the enzyme's expression.
Species Reactivity	Human;Mouse;Rat
Antigen	ACPP
Application	（Western blot）1：500-1：2000，（IHC）1：50-1：200，（ELISA）1：20000-1：40000。，。
Immunogen	A synthesized peptide derived from human ACPP.
MW	48kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography utilizing SulfoLink™ Coupling Resin was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.
Tissue specificity	Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Isoform 2 also expressed in the sarcolemma of skeletal muscle. Levels of this cellular isoform decreased in prostate cancer.
Posttranslational modification	N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated with partially sialylated triantennary complex oligosaccharides.Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms amyloid beta-sheet fibrils, SEVI (semen-derived enhancer of viral infection) which entrap HIV virions, attach them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea. Target cell attachment and enhancement of HIV infection is inhibited by surfen. Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection.
Celluar localization	Extracellular region or secreted;Lysosome;Nucleus;Plasma Membrane;
UniPort	P15309