Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-TNIK Polyclonal Antibody#abs138570

Please note that the price mentioned above is only for your reference. If you require detailed pricing information, please reach out to our seller Vecent. We kindly advise you to get in touch with Vecent for accurate pricing details. Western blot analysis TNIK using K562 whole cell lysates This...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs138570-100ug	1-2 Weeks	301.0
abs138570-50ug	1-2 Weeks	201.0

Overview
catalog	abs138570
Other names	Traf2 and NCK interacting kinase, also known as KIAA0551 or TNIK, is an enzyme with the EC number 2.7.11.1. In humans, it is encoded by the TNIK gene and is referred to as TNIK_HUMAN. TNIK is a protein kinase that interacts with the Traf2 and NCK proteins. Its role is to phosphorylate and regulate various cellular processes. This enzyme is of great interest to researchers, and further studies are being conducted to understand its functions and potential implications.
Source	Rabbit
Specificity	The expression of total TNIK can be detected using the TNIK Antibody, which specifically targets the endogenous levels of TNIK.
Species Reactivity	Human;Mouse
Predictive reaction species	Rabbit;Sheep;Dog;Bovine;
Antigen	TNIK
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human TNIK.
MW	155 kDa
Properties
Concentration	1mg/ml
purification	Purification of the antiserum was carried out using SulfoLink™ Coupling Resin through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to keep the item at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the item to multiple instances of freezing and thawing, as this can potentially degrade its quality. So, it's crucial to handle and store the item carefully to maintain its effectiveness and potency.
Storage buffer	This mixture contains Rabbit IgG dissolved in phosphate buffered saline with a pH value of 7.4. Additionally, it includes 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this solution at a temperature of -20 °C. It remains stable for a duration of 12 months starting from the date of receipt.
Target
Background	Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
Tissue specificity	Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.
Posttranslational modification	Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction.
Celluar localization	Cytoskeleton;Cytosol;Endosome;Extracellular region or secreted;Nucleus;Plasma Membrane;
UniPort	Q9UKE5