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Rabbit Anti-PTS Polyclonal Antibody#abs137607

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Description

Catalog-specification	Delivery time	USD price
abs137607-100ug	1-2 Weeks	301.0
abs137607-50ug	1-2 Weeks	201.0

Overview
catalog	abs137607
Other names	6-pyruvoyl tetrahydrobiopterin synthase, also known as 6-pyruvoyl tetrahydropterin synthase or PTP synthase, is an enzyme with the EC number 4.2.3.12. It plays a crucial role in the biosynthesis of tetrahydrobiopterin (BH4), an essential cofactor for various enzymes involved in neurotransmitter metabolism. The enzyme is encoded by the FLJ97081 gene and is also known as OTTHUMP00000235385 or PTPS_HUMAN. PTP synthase is responsible for the conversion of dihydroneopterin triphosphate (H2NTP) to 6-pyruvoyl tetrahydropterin (PTP), the final step in the BH4 biosynthetic pathway. This reaction involves the rearrangement of the H2NTP molecule, resulting in the formation of the pyruvoyl group on the pterin ring. Deficiencies in PTP synthase activity can lead to BH4 biosynthesis disorders, such as hyperphenylalaninemia (HPA). HPA is characterized by elevated levels of phenylalanine in the blood and can cause neurological symptoms if left untreated. Thus, PTP synthase plays a crucial role in maintaining proper neurotransmitter metabolism and overall neurological function. In conclusion, PTP synthase, also known as 6-pyruvoyl tetrahydrobiopterin synthase, is an enzyme involved in the biosynthesis of tetrahydrobiopterin. Its activity is essential for the proper functioning of various enzymes involved in neurotransmitter metabolism. Deficiencies in PTP synthase can lead to neurological disorders such as hyperphenylalaninemia.
Source	Rabbit
Specificity	The PTS Antibody is capable of recognizing total PTS present within the body. This means that it can specifically detect the levels of PTS that are naturally occurring in the body.
Species Reactivity	Human
Antigen	PTS
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human PTS.
MW	16 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	For a duration of one year, it is recommended to store the product at a temperature of -20 °C. It is essential to avoid repeated cycles of freezing and thawing to maintain the quality and efficacy of the product.
Storage buffer	This product is Rabbit IgG, which is preserved in a solution containing phosphate-buffered saline (pH 7.4), 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20 °C for optimal stability. The product remains stable for a period of 12 months starting from the date of receipt.
Target
Background	Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
Posttranslational modification	Phosphorylation of Ser-19 is required for maximal enzyme activity.
Celluar localization	Cytosol;Mitochondrion;
UniPort	Q03393