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Rabbit Anti-GYPC Polyclonal Antibody#abs135884

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Description

Catalog-specification	Delivery time	USD price
abs135884-100ug	1-2 Weeks	301.0
abs135884-50ug	1-2 Weeks	201.0

Overview
catalog	abs135884
Description	Glycophorin C (GYPC) is a vital integral membrane glycoprotein responsible for regulating the mechanical stability of red blood cells. Although it is a minor species found on human erythrocytes, its role is crucial. Various mutations have been identified in the glycophorin C gene. Deletion of exon 3 and 2 leads to the Gerbich and Yus phenotypes, respectively. On the other hand, the Webb and Duch antigens, also known as glycophorin D, result from single-point mutations in the glycophorin C gene. Unlike glycophorins A and B, the glycophorin C protein shows little resemblance to them. Furthermore, alternate splicing of the gene gives rise to multiple transcript variants. These findings were reported in February 2012 as part of the RefSeq database.
Other names	Glycophorin-C, also known as CD236 or Gerbich blood group antigen, is a glycoprotein that plays an important role in cell adhesion. It is encoded by the GYPC gene and is expressed on the surface of red blood cells. Its alternative isoform, glycophorin-D, is also involved in cell adhesion processes. Glycophorin-C and glycophorin-D are members of the glycophorin family, which includes other glycoproteins such as glycophorin beta and sialoglycoprotein D. These proteins are characterized by their presence of sialic acid residues and their involvement in various cellular functions. The CD236R isoform of glycophorin-C is a result of alternative splicing and differs from the CD236 isoform by having an additional repeat unit in its extracellular domain. This isoform is mainly expressed in the erythroid cells of the bone marrow. Another related protein is GLPC (Glycoconnectin), which is structurally similar to glycophorin-C and glycophorin-D. GLPC is also involved in cell adhesion and is encoded by the GLPC_HUMAN gene. In summary, these proteins, including CD236, CD236R, GLPC, GLPC_HUMAN, Glycoconnectin, and Glycophorin-D, are all members of the glycophorin family and play important roles in cell adhesion processes. They are expressed on the surface of red blood cells and are involved in various cellular functions.
Source	Rabbit
Specificity	The GYPC antibody is able to identify the total amount of endogenous GYPC present in the system. By detecting this protein, the antibody can provide valuable information about its levels and potential effects on cellular processes. Through careful analysis of the antibody's results, researchers can gain insight into the function and regulation of GYPC in the body. Overall, the GYPC antibody is a powerful tool for understanding the complexities of biological systems and the various signaling pathways that govern them.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Pig;Dog;
Antigen	GYPC
Application	The dilution factors for the WB assay are 1:500 to 1:2000, for the IHC assay are 1:50 to 1:200, and for the ELISA assay using peptide are 1:20000 to 1:40000. This information provides guidelines on the optimal dilutions to use when conducting these assays.
Immunogen	A synthesized peptide derived from human GYPC.
MW	14kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.
Tissue specificity	Glycophorin-C is expressed in erythrocytes. Glycophorin-D and IsoGPC are ubiquitously expressed.
Posttranslational modification	O-glycosylated with core 1 or possibly core 8 glycans.
Celluar localization	Cytoskeleton;Plasma Membrane;
UniPort	P04921