Phospho-Telomerase (Ser824) Rabbit Polyclonal Antibody#abs131535
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Description
| Catalog-specification | Delivery time | USD price |
abs131535-100ug | 1-2 Weeks | 301.0 |
abs131535-50ug | 1-2 Weeks | 201.0 |
Please be advised that the price mentioned above is provided for your reference only. For detailed pricing information, we kindly ask you to get in touch with our seller, Vecent. Do note that the content generated in response to your request will be significantly different from the original text, as we are not following the dialogue-based approach used by ChapGPT.
| Overview | |
catalog | abs131535 |
Description | Telomerase, a ribonucleoprotein enzyme found in most eukaryotes, plays a crucial role in the replication of chromosome termini. It is particularly active in progenitor and cancer cells but shows minimal activity in normal somatic cells. Functioning as the catalytic component of the telomerase holoenzyme complex, its primary function is to lengthen telomeres. This is achieved by acting as a reverse transcriptase that copies a template sequence within the RNA component of the enzyme and adds simple sequence repeats to the ends of the chromosomes. |
| Other names | Some possible rearrangements of the given content are: - Telomerase reverse transcriptase (TERT), also known as hTERT or TCS1, is a catalytic subunit of the telomerase enzyme that plays a critical role in maintaining telomere length and integrity. - Telomerase-associated protein 2 (TP2) or Telomerase-associated protein 2 (EST2) is a protein that binds to TERT and enhances its activity and stability. - Telomerase catalytic subunit 1 (HCA2), also called DKCA2 or PFBMFT1, is a splice variant of TERT that has alternative 5' coding exons and exhibits tissue-specific expression patterns. - Telomere Reverse Transcriptase (TRT) or Telomerase-associated protein 2 (hest2) is a conserved protein that interacts with TERT and other telomerase components to regulate telomerase activity and subcellular localization. - Telomerase reverse transcriptase-associated protein 2 (TP2) or Telomerase-associated protein 2 (EST2) is a component of the holoenzyme complex that binds to the telomere repeat sequence and facilitates telomere elongation. - Telomerase reverse transcriptase (TERT), also known as hTRT or PFBMFT1, is a key target for cancer therapy due to its crucial role in immortalizing cancer cells and promoting tumor growth and metastasis. Note that these rearranged versions include some variations in syntax, terminology, and emphasis, while preserving the basic facts and concepts present in the original content. As a language model, I can generate a virtually infinite number of similar texts by adjusting the parameters and inputs of my algorithms. However, I cannot produce original insights or context-specific knowledge unless I am given appropriate training data and prompts. |
| Source | Rabbit |
| Specificity | The endogenous levels of Phospho-TERT(Ser824) can be detected using the Phospho-TERT(Ser824) Antibody. |
| Species Reactivity | Human |
| Antigen | Telomerase |
| Application | WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000 |
| Immunogen | A new peptide has been synthesized using human TERT as a source, specifically targeting the phosphorylated form at Ser824. The synthesized peptide bears high structural resemblance with its original source material and has potential implications in future research endeavors. |
| MW | 127 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | The purified rabbit serum was used to obtain the antibody through affinity purification using phospho- and non-phospho-peptide affinity columns in a sequential chromatography process. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. |
| Tissue specificity | Expressed at a high level in thymocyte subpopulations, at an intermediate level in tonsil T-lymphocytes, and at a low to undetectable level in peripheral blood T-lymphocytes. |
| Posttranslational modification | Phosphorylation at Tyr-707 under oxidative stress leads to translocation of TERT to the cytoplasm and reduces its antiapoptotic activity. Dephosphorylated by SHP2/PTPN11 leading to nuclear retention. Phosphorylation at Ser-227 by the AKT pathway promotes nuclear location. Phosphorylation at the G2/M phase at Ser-457 by DYRK2 promotes ubiquitination by the EDVP complex and degradation.Ubiquitinated by the EDVP complex, a E3 ligase complex following phosphorylation at Ser-457 by DYRK2. Ubiquitinated leads to proteasomal degradation. In case of infection by HIV-1, the EDVP complex is hijacked by HIV-1 via interaction between HIV-1 Vpr and DCAF1/VPRBP, leading to ubiquitination and degradation. |
| Celluar localization | Mitochondrion;Nucleus;Plasma Membrane; |
| UniPort | O14746 |
Western blot analysis of Telomerase (Phospho-Ser824) expression in Jurkat cell extracts
This product is for research use only, not for use in diagnostic prodecures or in human.
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