Interleukin Genealogy - IL2
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Interleukin-2 (IL-2) is a small protein with a molecular weight of 15.5kDa and composed of 133 amino acid residues. It possesses three cysteine amino acids at positions 58, 105, and 125. The intra-chain disulfide bond formed by cysteine 58 and cysteine 105 is crucial for maintaining the biological activity of IL-2. T cells or T cell lines are the primary producers of IL-2. This cytokine is typically released by mitogen-stimulated CD4-positive or CD8-positive T cell subsets. The secretion of IL-2 by CD4-positive T cells is mainly triggered by alloantigens, whereas T cells located in the spleen, lymph nodes, and tonsils produce IL-2 when stimulated.
IL-2 has shown promising results in preventing tumor formation and stopping the growth of existing tumors. In clinical trials, IL-2 has been found to stimulate PBMC and TIL to turn into LAK cells, which are known to show significant anti-tumor activity in vitro. Renal cell carcinoma, melanoma, non-Hodgkin's lymphoma, and colorectal cancer have been found to respond well to LAK/IL-2 treatment. However, the response to IL-2 treatment may vary for other types of cancers such as liver, ovarian, bladder, and lung cancer.
Furthermore, IL-2 gene therapy has been tested in clinical trials for melanoma, renal cell carcinoma, and neuroblastoma, and the results have been positive. Additionally, IL-2 has been found to have anti-viral properties, and it can enhance the antiviral activity of CTL and NK cells, as well as stimulate the production of IFN-γ to combat viral infections caused by immune deficiency. Recently, IL-2 has also shown some promise in the treatment of active hepatitis and herpes simplex virus infection. Furthermore, it is being tested in the clinical validation of phase ⅱ for treating AIDS disease, nodular leprosy, mycobacterium tuberculosis infection, among others. With the many potential applications of IL-2, it has become an exciting area of research with promising clinical applications.
1. The following products are available for purchase: - SKU abs135615: Rabbit anti-IL2 Polyclonal Antibody, available in 50ul or 100ul sizes. - SKU abs125241: Rabbit anti-IL2 Polyclonal Antibody, available in 100ul size. - SKU abs133822: Rabbit anti-IL2 Polyclonal Antibody, available in 50ul size. - SKU abs520002: Mouse IL-2 ELISA KIT, available in 96T size. - SKU abs510001: Human IL-2 ELISA Kit, available in 96T size. - SKU abs04045: Recombinant Human Interleukin-2/IL-2, available in 10ug, 50ug, 500ug, or 1mg sizes. - SKU abs04100: Recombinant Mouse Interleukin-2/IL‐2, available in 10ug, 50ug, 500ug, or 1mg sizes. - SKU abs04096: Recombinant Human IL-2 Receptor Subunit α/IL-2RA/CD25 (C-6His), available in 10ug, 50ug, 500ug, or 1mg sizes. - SKU abs04279: Recombinant Mouse IL-2R α/IL-2RA/CD25 (C-6His), available in 10ug, 50ug, 500ug, or 1mg sizes.
2. We offer a range of products related to IL2, including antibodies, ELISA kits, and recombinant proteins. Our antibody products include Rabbit anti-IL2 Polyclonal Antibody in various sizes, while our ELISA kits cover both human and mouse IL-2. We also provide Recombinant Human and Mouse Interleukin-2/IL-2 in different sizes, as well as recombinant Human and Mouse IL-2R in alpha subunit form. Whatever your IL2 research needs, we have you covered with our high-quality products.
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